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Psychopharmacology

, Volume 126, Issue 3, pp 206–218 | Cite as

Effects of the selective angiotensin II receptor antagonists losartan and PD123177 in animal models of anxiety and memory

  • J. Shepherd
  • D. J. Bill
  • C. T. Dourish
  • S. S. Grewal
  • A. McLenachan
  • K. J. Stanhope
Original Investigation

Abstract

There is increasing interest in the potential functional role of the octapeptide angiotensin II (AII) in psychiatric and cognitive disorders. The novel angiotensin II (AII) receptor antagonists, losartan and PD123177, selective for the AT1 and AT2 receptor subtypes respectively, constitute important pharmacological tools for the assessment of the behavioural consequences of modulation of AII function. The present series of studies investigated the effects of each compound in two animal models of anxiety, the rat elevated zero-maze and mouse light/dark box, and two models of working memory in the rat, the operant delayed matching to position (DMTP) task and the spatial reinforced alternation test in the T-maze. Our data indicate that both compounds (0.01–10 mg/kg SC) were without significant effect in any of the behavioural assays. Using the present methods and strains of laboratory rodents, these findings provide no support for the involvement of AII receptor function in the mediation of anxiety or working memory.

Key words

Angiotensin II AT1 receptor AT2 receptor Losartan PD123177 Anxiety Working memory Elevated zero-maze Light/dark box Delayed matching to position test T-maze Cognition Rats Mice 

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Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • J. Shepherd
    • 1
  • D. J. Bill
    • 1
  • C. T. Dourish
    • 1
  • S. S. Grewal
    • 1
  • A. McLenachan
    • 1
  • K. J. Stanhope
    • 1
  1. 1.Department of NeuropharmacologyWyeth Research (UK) Ltd., Huntercombe Lane South, TaplowMaidenheadUK

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