Low dose melatonin improves sleep in healthy middle-aged subjects
- 252 Downloads
We studied the effects of single evening doses of melatonin (0.3 mg and 1.0 mg orally) on polysomnographically measured sleep in 15 healthy middle-aged volunteers, using a placebo-controlled, double-blind, cross-over design. Compared to placebo, the 1.0 mg dose of melatonin significantly increased Actual Sleep Time, Sleep Efficiency, non-REM Sleep and REM Sleep Latency. These data are consistent with the hypothesis that low dose melatonin has hypnotic effects in humans. It is possible that administered melatonin may have a role to play in the treatment of sleep disorders.
Key wordsMelatonin Sleep
Unable to display preview. Download preview PDF.
- Arendt J (1995) The pineal in human physiology and pathology. Biochemistry of the pineal. In: Arendt J (ed) Melatonin and the mammalian pineal gland. Chapman and Hall, London, pp. 201–206 and 27–65Google Scholar
- Waldhauser F, Saletu B, Trinchard-Lugan I (1990) Sleep laboratory investigations on hypnotic properties of melatonin. Psychopharmacology 100:222–226Google Scholar