Abstract
Circadian rhythm in the behavioral responsiveness to the selective 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) was studied in rats. Rats were subcutaneously injected with 8-OH-DPAT at one of the following times of day: 0000, 0400, 0800, 1200, 1600, 2000 hours. The postsynaptic 5-HT1A receptor behavioral syndrome, that is, forepaw treading, head weaving, and flat body posture, were measured after the administration of 8-OH-DPAT. Circadian rhythms were found in each of the behavioral responses to 8-OH-DPAT. Peak responses were observed in the mid-dark phase (1200 hours) while the weakest responses were observed in the midlight phase (0000 hours). In a subsequent experiment, 8-OH-DPAT was administered intracerebroventricularly during the mid-dark phase and the mid-light phase. The behavioral responses to the drug in the middark phase were significantly higher than those in the mid-light phase. These results suggest that the function of central postsynaptic 5-HT1A receptor exhibits circadian rhythm.
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References
Akiyoshi J, Kuranaga H, Tsuchiyama K, Nagayama H (1989) Circadian rhythm of serotonin receptor in rat brain. Pharmacol Biochem Behav 32:491–493
Barbaccia ML, Brunello N, Chaung DM, Costa E (1983) Serotoninelicited amplification of adenylate cyclase activity in hippocampal membranes of adult rat. J Neurochem 40:1671–1679
Berendsen HHG, Broekkamp CLE (1990) Behavioral evidence for functional interactions between 5-HT-receptor subtypes in rats and mice. Br J Pharmacol 101:667–673
Bovetto S, Richard D (1995) Functional assessment of the 5-HT1A−, 1B, 2A/2C−, and 3-receptor subtypes on food intake and metabolic rate in rats. Am J Physiol 268:R14-R20
Currie PJ, Coscina DV (1993) Diurnal variation in the feeding response to 8-OH-DPAT injected into the dorsal or median raphe. Neuroreport 4:1105–1107
Dermani NA, Martin BR, Pandey U, Glennon RA (1990) Do functional relationships exist between 5-HT1A and 5-HT2 receptors? Pharmacol Biochem behav 36:901–906
Edgar DM, Miller JD, Prosser RA, Dean RR, Dement WC (1993) Serotonin and the mammalian circadian system: II. Phaseshifting rat behavioral rhythms with serotonergic agonists. J Biol Rhythms 8:17–31
Goodwin GM, DeSouza RJ, Green AR (1985) The pharmacology of the hypothermic response in mice to 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). Neuropharmacology 24:1187–1194
Goodwin GM, DeSouza RJ, Green AR, Heal DJ (1987) The Pharmacology of the behavioral and hypothermic responses of rats to. Psychopharmacology 91:506–511
Jenni-Eiermann S, Von Hahn HP, Honergger CG (1986) Diurnal rhythms in neurotransmitter receptor binding and choline acetyltransferase activity: different patterns in two rat lines of Wistar origin. Brain Res 370:54–60
Lemmer B, Baermeier H, Schmidt S, Lang PH (1987) On the daily variation in the beta-receptor-adenylate cyclase-cAMP-phos-phodiesterase system in rat forebrain. Chronobiol Int 4:469–475
Martin KF, Marsden CA (1985) In vivo diurnal variations of 5-HT release in hypothalamic nuclei. In: Redfern PH, Campbell IC, Davies JA, Martin KF (eds) Circadian rhythms in the central Nervous system. Macmillan, London, pp 81–94
Moser PC, Redfern PH (1985a) Lack of variation over 24-hours in response to stimulation of 5-HT1 receptors in the mouse brain. Chronobiol Int 2:235–238
Moser PC, Redfern PH (1985b) Circadian variation in behavioral responses to central 5-HT receptor stimulation in the mouse. Psychopharmacology 86:223–227
Nagayama H (1993) Chronopharmacology of psychotropic drugs: circadian rhythms in drug effects and its implications to rhythms in the brain. Pharmacol Ther 59:31–54
Nagayama H, Takagi A, Tateishi T, Takahashi R (1977) Circadian susceptibility rhythm to neuroleptics: tetrabenazine. Psychopharmacology 55:61–66
Nagayama H, Nagano K, Ikezaki A, Tashiro T (1991) Doubleblind study of the chronopharmacotherapy of depression. Chronobiol Int 8:203–209
Penev PD, Zee PC, Wallen EP, Turek FW (1995) Aging alters the phase-resetting properties of a serotonin agonist hamster circadian rhythmicity. Am J Physiol 268:R293-R298
Pranzatelli MR, Pluchino Rs (1991) The relation of central 5-HT1A and 5-HT2 receptors: low dose agonist-induced selective tolerance in the rat. Pharmacol Biochem Behav 39:407–413
Smith LM, Peroutka SJ (1986) Differential effects of 5-hydroxy-tryptamine1A selective drugs on the 5-HT behavioral syndrome. Pharmacol Biochem Behav 24:1513–1519
Tominaga K, Shibata S, Ueki S, Watanabe S (1992) Effects of 5-HT1A receptor agonists on the circadian rhythm of wheel-running activity in hamsters. Eur J Pharmacol 214:79–84
Tricklebank MD, Forler C, Fozard J (1985) The involvement of subtypes of the 5-HT1 receptor and of catecholaminergic systems in the behavioral response to 8-hydroxy-2-(di-n-propylamino)tetralin in the rat. Eur J Pharmacol 106:271–282
Weiner N, Clement H-W, Gemsa D, Wesemann W (1992) Circadian and seasonal rhythms of 5-HT receptor subtypes, membrane anisotropy and 5-HT release in hippocampus and cortex of the rat. Neurochem Int 21:7–14
Wesemann W, Rotsch M, Schulz E, Sturm G, Zoefel (1986) Circadian rhythm of serotonin binding in rat. I. Effect of the light-dark cycle. Chronobiol Int 3:135–139
Yamada J, Sugimoto Y, Horisaka K (1988) The behavioral effects of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) in mice. Eur J Pharmacol 154:299–304
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Lu, JQ., Nagayama, H. Circadian rhythm in the response of central 5-HT1A receptors to 8-OH-DPAT in rats. Psychopharmacology 123, 42–45 (1996). https://doi.org/10.1007/BF02246279
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DOI: https://doi.org/10.1007/BF02246279