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Psychopharmacology

, Volume 106, Supplement 1, pp S127–S129 | Cite as

Safety of moclobemide taken in overdose for attempted suicide

  • W. Hetzel
Section V Special Patient Groups Mini-Paper

Abstract

Moclobemide is a reversible inhibitor of the monoamine oxidase type A. In clinical studies, more than 3900 patients have been treated with moclobemide for depression. Eighteen of these patients attempted suicide by overdosing moclobemide with or without other drugs. All patients recovered fully without leaving signs of cardio-or hepatotoxicity. Moclobemide can safely be prescribed for in- and out-patient treatment of depression.

Key words

Moclobemide MAO-A inhibitor Overdose 

References

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  3. Da Prada M et al. (1989) Preclinical profiles of the novel reversible MAO-A inhibitors, moclobemide and brofaromine, in comparison with irreversible MAO inhibitors. J Neural Transm Suppl 28:5–20Google Scholar
  4. Pöldinger W (1987) Incidence and evaluation of risk of suicide in depression. In: Bizière K, Garratini S, Simon P (eds) Proceedings of Symposium ‘Quo vadis?’: diagnosis and treatment of depression, May 11–12, 1987, Montpellier, FranceGoogle Scholar
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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • W. Hetzel
    • 1
  1. 1.Pharma Clinical Research DepartmentF. Hoffmann-La Roche LtdBaselSwitzerland

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