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The discriminative properties of the D1 dopamine agonist dihydrexidine in the rat

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Abstract

The objective of this study was to train rats to discriminate the interoceptive stimuli produced by a selective dopamine D1 agonist. Fourteen male Sprague-Dawley rats acquired the discrimination of the fully effective, high potency, D1 agonist dihydrexidine (DHX) within 20 sessions using a training dose of 3.0 mg/kg. DHX (0.75–4.5 mg/kg) dose-dependently increased DHX-appropriate responding with an ED50=1.44 mg/kg. The selective D1 agonist SKF 38398 (2.0–8.0 mg/kg) dose-responsively generalized with an ED50=3.54 mg/kg; significantly less potent than DHX. The selective D1 antagonist SCH 23390 (0.06–0.12 mg/kg) dose-responsively decreased DHX-appropriate discriminative performance. These data would indicate that DHX is a selective D1 agonist that may allow for testing of the selectivity of other putative D1 agonists in this experimental procedure. Administration of non-selective dopaminergically active drugs, including apomorphine, amphetamine and cocaine, were each shown to produce intermediate DHX-appropriate discriminative performance.

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Schechter, M.D. The discriminative properties of the D1 dopamine agonist dihydrexidine in the rat. Psychopharmacology 119, 79–84 (1995). https://doi.org/10.1007/BF02246057

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  • DOI: https://doi.org/10.1007/BF02246057

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