Psychopharmacology

, Volume 119, Issue 1, pp 9–14 | Cite as

Acute immobilization stress reduces (±DOI)-induced 5-HT2A receptor-mediated head shakes in rats

  • S. Yamada
  • A. Watanabe
  • M. Nankai
  • M. Toru
Original Investigation

Abstract

Acute immobilization stress induced by taping four limbs, applying tail pinch stress and electric foot shock stress immediately reduced the frequency of head shakes induced by 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane ((±)DOI), a 5-HT2A/C agonist in rats. Immobilization stress due to the use of cylinder restraint and forced swimming did not affect 5-HT2A-mediated behavior. Acute immobilization stress did not affect [3H]ketanserin binding to the 5HT2A receptor in the prefrontal cortex and hippocampus. Presynaptic serotonergic lesions with 5,7-dihydroxytryptamine (5,7-DHT) did not affect the reduction in 5-HT2A-mediated behavior after acute immobilization stress. The decreases in head shake frequency after acute immobilization stress by taping were attenuated by pretreatment with diazepam (2.5 mg/kg IP): This attenuation was reversed by pretreatment with flumazenil (10 mg/kg IP). The reduction in (±)DOI- induced 5-HT2A-mediated behavior caused by stress may be related to a change in agonist affinity to the receptor or changes in other neurotransmitter systems or the effect of PI turnover.

Key words

DOI (1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane) 5-HT2A Head shake Diazepam Immobilization stress [3H]Ketanserin binding 5,7-DHT (5,7-dihydroxytryptamine) 

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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • S. Yamada
    • 1
  • A. Watanabe
    • 1
  • M. Nankai
    • 1
  • M. Toru
    • 1
  1. 1.Department of Neuropsychiatry, Faculty of MedicineTokyo Medical and Dental UniversityBunkyo-ku, TokyoJapan

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