, Volume 104, Issue 4, pp 496–504 | Cite as

Signs and symptoms from nicotine gum abstinence

  • Dorothy K. Hatsukami
  • Kelli Skoog
  • Marguerite Huber
  • John Hughes
Original Investigations


This study examined and compared withdrawal signs and symptoms from cessation of 0, 2 and 4 mg nicotine gum. In addition, a comparison was made between nicotine gum versus cigarette withdrawal symptoms. Smokers first underwent cigarette deprivation for 4 days and then were randomly assigned to 0 (N=16), 2 (N=25), and 4 (N=21) mg gum. They were asked to chew the gum for 1 month and then to undergo a 4-day nicotine gum deprivation period. The results showed a number of significant changes occurring after deprivation from 4 mg gum, one change from 2 mg gum, and no changes from 0 mg gum. There were no significant differences in severity of withdrawal among the various doses of nicotine gum. There were more severe symptoms of withdrawal from cigarette as opposed to 4 mg nicotine gum deprivation.

Key words

Nicotine gum Cigarette Withdrawal 


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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • Dorothy K. Hatsukami
    • 1
  • Kelli Skoog
    • 1
  • Marguerite Huber
    • 1
  • John Hughes
    • 2
  1. 1.Department of PsychiatryUniversity of MinnesotaMinneapolisUSA
  2. 2.Department of Psychiatry, College of MedicineUniversity of VermontBurlingtonUSA

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