Abstract
Male Wistar rats with continuous access to 6% ethanol solution and water in their home cages were subjected to food restriction (FR). Reduction of body weight to 80% of normal was associated with a significant increase in ethanol drinking. It is known that the stress of FR gives rise to increased corticosterone secretion, and in line with these findings it was found that the weight of the thymus (whose size is inversely related to corticosterone levels) was reduced to 55% of normal in the present FR rats. Two subsequent experiments indicated that this adrenal activation contributed to the FR-induced enhancement of alcohol drinking. Firstly, adrenalectomized rats showed no evidence of enhanced alcohol drinking during food restriction, suggesting that adrenal corticosterone hypersecretion contributes to the enhanced ethanol consumption during FR. Secondly, treatment of FR rats with the enzyme inhibitor cyanoketone, which blocks stress-induced but not basal corticosterone secretion, at least partly prevented the FR-induced increase in ethanol drinking. These results add further evidence that sustained exposure to corticosterone facilitates ethanol consumption in the rat.
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References
Akana SF, Shinsako J, Dallman MF (1983) Drug-induced adrenal hypertrophy provides evidence for reset in the adrenocortical system. Endocrinol 113:2232–2237
Akana SF, Cascio CS, Shinsako J, Dallman MF (1985) Corticosterone: narrow range required for normal body and thymus weight and ACTH. Am J Physiol 363:R527-R532
Bednar I, Forsberg G, Lindén A, Qureshi GA, Södersten P (1991) Involvement of dopamine in inhibition of food intake by cholecystokinin octapeptide in male rats. J Neuroendocrinol 3:491–496
Broocks A, Schweiger U, Pirke KM (1990) Hyperactivity aggravates semistarvation-induced changes in corticosterone and triodothyronine concentrations in plasma but not luteinizing hormone and testosterone levels. Physiol Behav 48:567–569
Broocks A, Schweiger U, Pirke KM (1991) The influence of semistarvation-induced hyperactivity on hypothalamic serotonin metabolism. Physiol Behav 50:385–388
Burlet AJ, Jhanwar-Uniyal M, Chapleur-Chateau M, Burlet CR, Leibowitz SF (1992) Effect of food deprivation and refeeding on the concentration of vasopressin and oxytocin in discrete hypothalamic sites. Pharmacol Biochem Behav 43:897–905
Cabanac M (1971) Physiological role of pleasure. Science 173:1103–1107
Cador M, Dulluc J, Mormède P (1993) Modulation of the locomotor response to amphetamine by corticosterone. Neuroscience 56:981–988
Campbell BA, Fibiger HC (1971) Potentiation of amphetamine-induced arousal by starvation. Nature 233:424–425
Carroll ME, France CP, Meisch RA (1979) Food deprivation increases oral and intravenous drug intake in rats. Science 205:319–321
Dallman MF, Akana SF, Scribner KA, Bradbury MJ, Walker C-D, Strack AM, Cascio CS (1992) Stress, feedback and facilitation in the hypothalamo-pituitary-adrenal axis. J Neuroendocrinol 4:517–526
De Vry J, Donselaar I, Van Ree JM (1989) Food deprivation and acquisition of intravenous cocaine self-administration in rats: effects of naltrexone and haloperidol. J Pharmacol Exp Ther 251:735–740
Deroche V, Piazza PV, Casolini P, Le Moal M, Simon H (1993) Sensitization to the psychomotor effects of amphetamine and morphine induced by food restriction depends on corticosterone secretion. Brain Res 611:352–356
Fahlke C, Engel JA, Eriksson CJP, Hård E, Söderpalm B (1994a) Involvement of corticosterone in the modulation of ethanol consumption in the rat. Alcohol 11:195–202
Fahlke C, Hård E, Thomasson R, Engel JA, Hansen S (1994b) Metyrapone-induced suppression of corticosterone synthesis reduces ethanol consumption in high-preferring rats. Pharmacol Biochem Behav 48:977–981
Fahlke C, Thomasson R, Hård E, Engel JA, Hansen S (1994c) Taste reactivity to alcohol in rats: influence of adrenalectomy or ipsapirone. Alcohol 11:284–294
Fahlke C, Hård E, Eriksson CPJ, Engel JA, Hansen S (1995) Consequence of long-term exposure to corticosterone or dexamethasone on ethanol consumption in the adrenalectomized rat, and the effect of type I and type II corticosterone receptor antagonists. Psychopharmacology 117:216–224
Garcia-Belenguer S, Oliver C, Mormède P (1993) Facilitation and feedback in the hypothalamo-pituitary-adrenal axis during food restriction in rats. J Neuroendocrinol 5:663–668
Goldbloom DS (1993) Alcohol misuse and eating disorders: aspects of an association. Alcohol Alcohol 28:375–381
Hamm RJ, Knisely JS, Watson A, Lyeth BG, Bossut DFB (1985) Hormonal mediation of the analgesia produced by food deprivation. Physiol Behav 35:879–882
Hansen S, Fahlke C, Hård E, Engel JA (1994) Adrenal corticosteroids modulate the coumption of ethanol in the rat. In: Palomo T, Archer T (eds) Strategies for studying brain disorders: depressive, anxiety and abuse disorders, vol. 1. Farand Press, London, pp 465–479
Higley JD, Hasert MF, Suomi SJ, Linnoila M (1991) Nonhuman primate model of alcohol abuse: effects of early experience, personality, and stress on alcohol consumption. Proc Natl Acad Sci USA 88:7261–7265
Hunsicker KD, Mullen BJ, Martin RJ (1992) Effect of starvation or restriction on self-selection of macronutrients in rats. Physiol Behav 51:325–330
Jhanwar-Uniyal M, Darwish M, Levin BE, Leibowitz SF (1987) Alterations in catecholamine levels and turnover in discrete brain areas after food deprivation. Pharmacol Biochem Behav 26:271–275
Kendler KS, Heath AC, Neale MC, Kessler RC, Eaves LJ (1993) Alcoholism and major depression in women. A twin study of the causes of comorbidity. Arch Gen Psychiatry 50:690–698
Klein F, Lemaire V, Sandi C, Vitiello S, Van Der Logt J, Laurent PE, Neveu P, Le Moal M, Mormède P (1992) Prolonged increase of corticosterone secretion by chronic social stress does not necessarily impair immune function. Life Sci 50:723–731
Kulkosky PJ (1985) Brain-gut neuropeptides and the limitation of ethanol consumption. Neurosci Biobehav Rev 9:179–190
Leibowitz SF (1992) Neurochemical-neuroendocrine systems in the brain controlling macronutrient intake and metabolism. Trends Neurosci 15:491–496
Lester D, Freed EX (1972) The rat views alcohol-nutrition or nirvana? Finnish Found Alcohol Stud 20:51–57
Levin N, Akana SF, Jacobson L, Kuhn RW, Siiteri PK, Dallman MF (1987) Plasma adrenocorticotropin is more sensitive than transcortin production or thymus weight to inhibition by corticosterone in rats. Endocrinology 121:1104–1109
Lindén A, Uvnäs-Moberg K, Forsberg G, Bednar I, Södersten P (1989) Plasma concentrations of cholecystokinin octapeptide and food intake in male rats treated with cholecystokinn octapeptide. J Neuroendocrinol 121:59–65
Linseman MA (1989) Effects of weight restriction and palatibility on the apparent pharmacological regulation of alcohol consumption by rats in a limited access paradigm. Appetite 12:153–159
Linseman MA, Harding S (1989) Alcohol consumption following bidirectional shifts in body weight in rats. Psychopharmacology 97:103–107
Mardones J (1972) Experimentally induced changes in alcohol appetite. Finnish Found Alcohol Stud 20:15–23
Margariños AM & McEwen BS (1993) Blockade of glucocorticoid synthesis by cyanoketone prevents chronic stress-induced dendritic atrophy of hippocampal neurons in the rat. Soc Neuroscience Abstr 19:71.2
Meisch RA, Thompson T (1972) Ethanol reinforcement: effects of concentration during food deprivation. Finnish Found Alcohol Stud 20:71–75
Meisch RA, Thompson T (1974) Ethanol intake as a function of concentration during food deprivation and satiation. Pharmacol Biochem Behav 2:589–596
Mitev Y, Almeida OFX, Patchev V (1993) Pituitary-adrenal function and hypothalamic beta-endorphin release in vitro following food deprivation. Brain Res Bull 30:7–10
O'Shea RD, Gundlach AL (1993) Regulation of cholecystokinin receptors in the hypothalamus of the rat: reciprocal changes in magnocellular nuclei induced by food deprivation and dehydration. J Neuroendocrinol 5:697–704
Pohorecky LA (1981) The interaction of alcohol and stress: a review. Neurosci Biobehav Rev 5:209–229
Richter CP (1941) Alcohol as food. Q J Study Alcohol 1:650–662
Richter CP, Campbell K (1940) Alcohol taste thresholds and concentrations of solution preferred by rats. Science 91:507–508
Rieg TS, Aravich PF (1994) Systemic clonidine increases feeding and wheel running but does not affect rate of weight loss in rats subjected to activity-based anorexia. Pharmacol Biochem Behav 47:215–218
Roehrs TE, Samson HH (1981) Ethanol-reinforced behavior assessed with a concurrent schedule. Pharmacol Biochem Behav 15:539–544
Sayette MA (1993) An appraisal-disruption model of alcohol's effects on stress responses in social drinkers. Psychol Bull 114:459–476
Shaham Y (1993) Immobilization stress-induced oral opioid self-administration and withdrawal in rats: role of conditioning factors and the effect of stress on “relapse” to opioid drugs. Psychopharmacology 111:477–485
Weingarten HP, Gowans SE (1991) Sensory control of eating. The meal as a stream of sensations. In Getchell TV, Doty RL, Bartoshuk LM, Snow JB (eds) Smell and taste in health and disease. Raven, New York, pp 381–389
Wilckens T, Schweiger U, Pirke KM (1992) Activation of 5-HT1C-receptors suppresses excessive wheel running induced by semistaravation in the rat. Psychopharmacology 109:77–84
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Hansen, S., Fahlke, C., Söderpalm, A.H.V. et al. Significance of adrenal corticosteroid secretion for the food restriction-induced enhancement of alcohol drinking in the rat. Psychopharmacology 121, 213–221 (1995). https://doi.org/10.1007/BF02245632
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DOI: https://doi.org/10.1007/BF02245632