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Psychopharmacology

, Volume 115, Issue 4, pp 435–440 | Cite as

CCK-A and CCK-B selective receptor agonists and antagonists modulate olfactory recognition in male rats

  • M. Lemaire
  • G. A. Böhme
  • O. Piot
  • B. P. Roques
  • J. -C. Blanchard
Original Investigations

Abstract

Modulation of learning and memory is one of the physiological roles that the neuropeptide cholecystokinin (CCK-8) may play. We have used a behavioural model of olfactory recognition among rats to test this hypothesis and to explore the relationship between CCK-A and CCK-B receptors and memory retention. Adult male rats form a transient memory of a juvenile congenere as indicated by a reduction in the duration of investigatory behaviour upon re-exposure 30 min after an initial exposure, but not when re-exposure is delayed until 120 min afterwards. In the present study, rats were treated after the first contact with various compounds; inhibition and facilitation of olfactory recognition were evaluated as the persistence in investigation 30 min and the decrease in investigation 120 min after pharmacological manipulations, respectively. Systemic injection of CCK-8, of a selective CCK-A agonist, or of non-peptide CCK-B antagonists (CI-988 and LY-262691) enhanced olfactory recognition. In contrast, the CCK-B selective agonist BC 264 and the tetrapeptide CCK-4 both disrupted it. Taken together with previous evidence of the detrimental effect of the non-peptide CCK-A antagonist devazepide on olfactory recognition, these results confirm and extend the hypothesis that there is a balance between CCK-A-mediated facilitative effects and CCK-B-mediated inhibitory effects on memory retention.

Key words

Behaviour Olfactory recognition Social investigation Neuropeptides Cholecystokinin Rat 

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Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • M. Lemaire
    • 1
  • G. A. Böhme
    • 1
  • O. Piot
    • 1
  • B. P. Roques
    • 2
  • J. -C. Blanchard
    • 1
  1. 1.Département de BiologieRhône-Poulenc Rorer S.A., Centre de Recherches de Vitry-AlfortvilleVitry-sur-Seine CedexFrance
  2. 2.INSERM U266-CNRS UA498, Faculté de PharmacieParisFrance

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