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Psychopharmacology

, Volume 111, Issue 2, pp 202–206 | Cite as

Self-administration of GBR 12909 on a fixed ratio and progressive ratio schedule in rats

  • David C. S. Roberts
Original Investigations

Abstract

Intravenous self-administration of GBR 12909, an indirect dopamine agonist, was examined on a Fixed Ratio (FR 1) and a Progressive Ratio (PR) schedule of reinforcement in rats. Subjects were first trained to self-administer cocaine (1.5 mg/kg/inj) during daily 5 h sessions, after which GBR 12909 (0.187–1.5 mg/kg/inj) was substituted. On the FR 1 schedule, the inter-infusion interval for GBR 12909 self-administration was directly related to dose and was approximately three times longer than that established for equivalent doses of cocaine. Breaking points on the PR schedule were comparable for GBR 12909 and cocaine self-administration. The data indicate that, compared to cocaine, GBR 12909 has a longer duration of action and a similar reinforcing efficacy.

Key words

GBR 12909 Cocaine Self-administration Progressive ratio schedule Fixed ratio Rats 

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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • David C. S. Roberts
    • 1
  1. 1.Life Sciences Research Building, Department of PsychologyCarleton UniversityOttawaCanada

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