Advertisement

Psychopharmacology

, Volume 111, Issue 2, pp 134–138 | Cite as

Strain-dependent effects of post-training GABA receptor agonists and antagonists on memory storage in mice

  • Claudio Castellano
  • Vincenzo Cestari
  • Simona Cabib
  • Stefano Puglisi-Allegra
Original Investigations

Abstract

Post-training administration of the GABA-A and GABA-B receptor agonists muscimol and baclofen dose-dependently impaired retention of an inhibitory avoidance response in C57 mice, while improving memory consolidation in the DBA strain. By contrast, picrotoxin (blocker of GABA-activated ionophores), bicuculline (GABA-A antagonist) and CGP 35348 (GABA-B antagonist) dose-dependently improved retention in C57 mice and impaired it in DBA mice. These effects cannot be ascribed to non-specific actions of the drugs on retention performance, as the latencies during the retention test of those mice that had not received footshock during the training were not lengthened by the post-training drug administration. The effects on retention performance induced by GABA agonists and antagonists are probably due to an effect on memory consolidation, since they are observed when the drugs are given at short, but not at long, intervals after training. These results are discussed in terms of possible interaction of GABA systems with endogenous opioid and dopamine systems, whose activation has been shown to produce strain-dependent effects on memory processes. The possible utilization of these results for a genetic behavioral approach with recombinant inbred (RI) mice is also considered.

Key words

GABA-A GABA-B receptors Memory Strain difference One-trial inhibitory avoidance Mouse 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Brioni JD, Nagahara AH, McGaugh JL (1989) Involvement of the amygdala GABAergic system in the modulation of memory storage. Brain Res 487:105–112CrossRefPubMedGoogle Scholar
  2. Cage PW (1992) Activation and modulation of neural K+ channels by GABA. TINS 15:46–51PubMedGoogle Scholar
  3. Castellano C (1975) Effects of morphine and heroin on discrimination learning and consolidation in mice. Psychopharmacologia 42:235–242CrossRefPubMedGoogle Scholar
  4. Castellano C (1980) Dose dependent effects of heroin on memory in two inbred strains of mice. Psychopharmacology 67:235–239CrossRefPubMedGoogle Scholar
  5. Castellano C (1981) Strain dependent effects of naloxone on discrimination learning in mice. Psychopharmacology 73:152–156CrossRefPubMedGoogle Scholar
  6. Castellano C, Puglisi-Allegra S (1983a) Strain-dependent modulation of memory by stress in mice. Behav Neural Biol 38:133–138CrossRefPubMedGoogle Scholar
  7. Castellano C, Puglisi-Allegra S (1983b) Effects of stress on memory processes in mice. In: Endroczi J (ed) Neuropeptides and psychosomatic processes. Publishing House of the Hungarian Academy of Science, Budapest, pp 111–117Google Scholar
  8. Castellano C, McGaugh JL (1989) Retention enhancement with post-training picrotoxin: lack of state dependency. Behav Neural Biol 51:165–170CrossRefPubMedGoogle Scholar
  9. Castellano C, McGaugh JL (1990) Effects of post-training bicuculline and muscimol on retention: lack of state dependency. Behav Neural Biol 54:156–164CrossRefPubMedGoogle Scholar
  10. Castellano C, Introini-Collison IB, Pavone F, McGaugh JL (1989) Effects of naloxone and naltrexone on memory consolidation in CD1 mice: involvement of GABAergic mechanisms. Pharmacol Biochem Behav 32:563–567CrossRefPubMedGoogle Scholar
  11. Castellano C, Brioni JD, McGaugh JL (1990) Gabaergic modulation of memory In: Squire L, Lindelaub E (eds) Biology of memory. Schattauer, Stuttgart New York, pp 361–378Google Scholar
  12. Castellano C, Cestari V, Cabib S, Puglisi-Allegra S (1991) Post-training dopamine receptor agonists and antagonists affect memory storage in mice irrespective of their selectivity for D1 or D2 receptors. Behav Neural Biol 56:283–291CrossRefPubMedGoogle Scholar
  13. Cattabeni F, Bugatti A, Groppetti A, Maggi A, Parenti M, Racagni G (1979) GABA and dopamine: their mutual regulation in the nigro-striatal system. In: Krogsgaard-Larsen P, Scheel-Kruger J, Kofod H (eds) GABA-neurotransmitters. Munsksgard, Copenhagen, pp 107–117Google Scholar
  14. Cestari V, Castellano C, Cabib S, Puglisi-Allegra S (1992) Strain-dependent effects of post-training dopamine receptor agonists and antagonists on memory storage in mice. Behav Neural Biol 58:58–63CrossRefPubMedGoogle Scholar
  15. Clement J, Simler S, Ciesielski L, Mandel P, Cabib S, Puglisi-Allegra S (1987) Age-dependent changes of brain GABA levels, turnover rates and shock-induced aggressive behavior in inbred strains of mice. Pharmacol Biochem Behav 26:83–88CrossRefPubMedGoogle Scholar
  16. Gold PE, McGaugh JL (1975). A single-trace, two-process view of memory storage processes. In: Deutsch D., Deutsch JA (eds) Short-term memory. Academic Press, New York, pp 355–378Google Scholar
  17. Gold PE, Zornetzer, SF (1983) The mnemon and its juices: neuromodulation of memory processes. Behav Neural Biol 38:151–189CrossRefPubMedGoogle Scholar
  18. Gora-Maslak G, McClearn GE, Crabbe JC, Phillips TJ, Belknap JK, Plomin R (1991) Use of recombinant inbred strains to identify quantitative trait loci in psychopharmacology. Psychopharmacology 104, 413–424PubMedGoogle Scholar
  19. McGaugh JL (1989) Involvement of hormonal and neuromodulatory systems in the regulation of memory storage. Annu Rev Neurosci 12:255–287CrossRefPubMedGoogle Scholar
  20. McGaugh JL, Landfield PW (1970) Delayed development of amnesia following electro-convulsive shock. Physiol Behav 5:1109–1113CrossRefPubMedGoogle Scholar
  21. McGaugh JL, Introini-Collison IB, Nagahara AH (1988) Memoryenhancing effects of post-training naloxone: involvement of β-noradrenergic influences in the amygdaloid complex. Brain Res 95:132–134Google Scholar
  22. Plomin R (1990) The role of inheritance in behavior. Science 183, 183–188Google Scholar
  23. Puglisi-Allegra S, Cabib S (1993) Dopamine and GABA in aggression and defense. In: Miczek KA, Liebman JM, Cooper SJ (eds) Neuropharmacology of aggressive behavior. Oxford University Press, Oxford (in press)Google Scholar
  24. Puglisi-Allegra S, Mack G, Oliverio A, Mandel P (1979) Effects of apomorphine and sodium di-n-propylacetate on the aggressive behavior of three strains of mice. Prog Neuropsychopharmacol 3:491–502PubMedGoogle Scholar
  25. Puglisi-Allegra S, Simler S, Kempf E, Mandel P (1981) Involvement of the GABAergic system on shock-induced aggressive behavior in two strains of mice. Pharmacol Biochem Behav 14[Suppl 11]:13–18PubMedGoogle Scholar
  26. Puglisi-Allegra S, Cabib S, Ebel A, Kempf J, Castellano C (1986) Passive avoidance behavior in mice: interaction between age and genotype. Exp Aging Res 12[2]:107–109PubMedGoogle Scholar
  27. Simler S, Puglisi-Allegra S, Mandel P (1982) γ-aminobutyric acid in brain areas of isolated aggressive and non-aggressive inbred strains of mice. Pharmacol Biochem Behav 16:57–71CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • Claudio Castellano
    • 1
  • Vincenzo Cestari
    • 1
  • Simona Cabib
    • 1
  • Stefano Puglisi-Allegra
    • 2
  1. 1.Istituto di Psicobiologia e Psicofarmacologia (C.N.R.)RomaItaly
  2. 2.Dipartimento di PsicologiaUniversità di Roma “La Sapienza”Italy

Personalised recommendations