Strain-dependent effects of post-training GABA receptor agonists and antagonists on memory storage in mice
- 54 Downloads
Post-training administration of the GABA-A and GABA-B receptor agonists muscimol and baclofen dose-dependently impaired retention of an inhibitory avoidance response in C57 mice, while improving memory consolidation in the DBA strain. By contrast, picrotoxin (blocker of GABA-activated ionophores), bicuculline (GABA-A antagonist) and CGP 35348 (GABA-B antagonist) dose-dependently improved retention in C57 mice and impaired it in DBA mice. These effects cannot be ascribed to non-specific actions of the drugs on retention performance, as the latencies during the retention test of those mice that had not received footshock during the training were not lengthened by the post-training drug administration. The effects on retention performance induced by GABA agonists and antagonists are probably due to an effect on memory consolidation, since they are observed when the drugs are given at short, but not at long, intervals after training. These results are discussed in terms of possible interaction of GABA systems with endogenous opioid and dopamine systems, whose activation has been shown to produce strain-dependent effects on memory processes. The possible utilization of these results for a genetic behavioral approach with recombinant inbred (RI) mice is also considered.
Key wordsGABA-A GABA-B receptors Memory Strain difference One-trial inhibitory avoidance Mouse
Unable to display preview. Download preview PDF.
- Castellano C, Puglisi-Allegra S (1983b) Effects of stress on memory processes in mice. In: Endroczi J (ed) Neuropeptides and psychosomatic processes. Publishing House of the Hungarian Academy of Science, Budapest, pp 111–117Google Scholar
- Castellano C, Brioni JD, McGaugh JL (1990) Gabaergic modulation of memory In: Squire L, Lindelaub E (eds) Biology of memory. Schattauer, Stuttgart New York, pp 361–378Google Scholar
- Cattabeni F, Bugatti A, Groppetti A, Maggi A, Parenti M, Racagni G (1979) GABA and dopamine: their mutual regulation in the nigro-striatal system. In: Krogsgaard-Larsen P, Scheel-Kruger J, Kofod H (eds) GABA-neurotransmitters. Munsksgard, Copenhagen, pp 107–117Google Scholar
- Gold PE, McGaugh JL (1975). A single-trace, two-process view of memory storage processes. In: Deutsch D., Deutsch JA (eds) Short-term memory. Academic Press, New York, pp 355–378Google Scholar
- McGaugh JL, Introini-Collison IB, Nagahara AH (1988) Memoryenhancing effects of post-training naloxone: involvement of β-noradrenergic influences in the amygdaloid complex. Brain Res 95:132–134Google Scholar
- Plomin R (1990) The role of inheritance in behavior. Science 183, 183–188Google Scholar
- Puglisi-Allegra S, Cabib S (1993) Dopamine and GABA in aggression and defense. In: Miczek KA, Liebman JM, Cooper SJ (eds) Neuropharmacology of aggressive behavior. Oxford University Press, Oxford (in press)Google Scholar