Abstract
Morphine (10 mg/kg, SC) in combination with ICV vehicle induced a significant hyperthermic effect at 120 min (peak time) after injection compared to ICV vehicle plus SC saline (control group). Glibenclamide (50 µg, ICV), a selective adenosine triphosphate-sensitive potassium (KATP) channel blocker, in combination with SC saline hardly affected the rectal temperature compared to the control group. ICV glibenclamide antagonized the hyperthermia induced by SC morphine in a dose-dependent manner. From these results, we demonstrated that KATP channels play an important role as modulators of the hyperthermic effect of μ agonists.
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Narita, M., Suzuki, T., Misawa, M. et al. Role of central ATP-sensitive potassium channels in the hyperthermic effect of morphine in mice. Psychopharmacology 109, 239–240 (1992). https://doi.org/10.1007/BF02245507
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DOI: https://doi.org/10.1007/BF02245507