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Effects of physostigmine on stimulus encoding in a memory-scanning task

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Abstract

Previous studies of the effects of physostigmine on memory have involved other drugs, a memory that has already been impaired, or both, often with contradictory results. Also, traditional memory tests do not differentiate memory from other task components such as perception and response, and drug effects on these could be mistaken for effects on memory. The present study was designed to investigate the effects of physostigmine alone on normal memory using Sternberg's additive-factor, memory-scanning task, with additional variables to isolate effects on stimulus encoding and response stages. Sixteen volunteers participated, the design was between-groups, and physostigmine or normal saline was given, double-blind, by intravenous infusion for 70 min. The drug had no effect on the memory component of the task, but significantly improved stimulus encoding (P<0.001). Thus, it is possible that physostigmine improves performance on memory tests by improving perception as well as, or instead of, memory.

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References

  • Ashford JW, Soldinger S, Schaeffer J, Cochran L, Jarvik LF (1981) Physostigmine and its effect on 6 patients with dementia. Am J Psychiatry 138:829–830

    PubMed  Google Scholar 

  • Baddeley AD (1976) The psychology of memory. Basic Books, New York

    Google Scholar 

  • Baddeley AD (1988) But what the hell is it for? In: Gruneberg MM, Morris PE, Sykes RN (eds) Practical aspects of memory, vol 1. Wiley, London, pp 3–18

    Google Scholar 

  • Caltagirone C, Gainotti G, Masullo C (1982) Oral administration of chronic physostigmine does not improve cognitive or mnesic performances in Alzheimer's presenile dementia. Int J Neurosci 16:247–249

    PubMed  Google Scholar 

  • Caltagirone C, Albanese A, Gainotti G, Masullo C (1983) Acute administration of individual optimal dose of physostigmine fails to improve mnesic performances in Alzheimer's presenile dementia. Int J Neurosci 18:143–147

    PubMed  Google Scholar 

  • Davies KL, Mohs RC (1982) Enhancement of memory processes in Alzheimer's disease with multiple-dose intravenous physostigmine. Am J Psychiatry 139:1421–1424

    PubMed  Google Scholar 

  • Davies KL, Hollister LE, Overall J, Johnson A, Train K (1976) Physostigmine: effects on cognition and affect in normal subjects. Psychopharmacology 51:23–27

    Article  PubMed  Google Scholar 

  • Davies KL, Mohs RC, Tinklenberg JR, Pfefferbaum A, Hollister LE, Kopell BS (1978) Physostigmine: improvement of long-term memory processes in normal human. Science 201:272–274

    Google Scholar 

  • Drachman DA, Sahakian BJ (1979) Effects of cholinergic agents on human learning and memory. In: Barbeau A, Growdon JH, Wurtman RJ (eds) Nutrition and the brain, vol 5. Raven Press, New York, pp 351–366

    Google Scholar 

  • Ghoneim MM, Mewaldt SP (1977) Studies on human memory: the interactions of diazepam, scopolamine and physostigmine. Psychopharmacology 52:1–6

    Article  PubMed  Google Scholar 

  • Graboi D (1971) Searching for targets: the effects of specific practice. Percept Psychophys 10:300–304

    Google Scholar 

  • Levin HS, Peters BH (1984) Long-term administration of oral physostigmine and lecithin improve memory in Alzheimer's disease. Ann Neurol 15:210

    Article  Google Scholar 

  • Liljequist R, Mattila MJ (1979) Effect of physostigmine and scopolamine on the memory functions of chess players. Med Biol 57:402–405

    PubMed  Google Scholar 

  • Maizlish NA, Langolf GD, Whitehead LW, Fine LJ, Albers JW, Goldberg J and Smith PJ (1985) Behavioural evaluation of workers exposed to mixtures of organic solvents. Br J Ind Med 42:579–590

    PubMed  Google Scholar 

  • Mayer SE, Bain JA (1956) Localisation of the hematoencephalic barrier with fluorescent quaternary acridones. J Pharmacol Exp Ther 118:17–25

    PubMed  Google Scholar 

  • McNair DM, Kahn RJ, Frankenthaler LM, Faldetta LL (1984) Amoxapine and amitriptyline II: specificity of cognitive effects during brief treatment of depression. Psychopharmacology 83:134–139

    Article  PubMed  Google Scholar 

  • Mewaldt SP, Ghoneim MM (1979) The effects and interactions of scopolamine, physostigmine and methamphetamine on human memory. Pharmacol Biochem Behav 10:205–210

    Article  PubMed  Google Scholar 

  • Millar K (1991) The recovery of memory function. In: Klepper ID, Sanders LD, Rosen M (eds) Ambulatory anaesthesia and sedation: impairment and recovery. Blackwell, Oxford

    Google Scholar 

  • Mohs RC, Tinklenberg JR, Roth WY, Kopell BS (1980) Sensitivity of some human cognitive functions to effects of methamphetamine and secobarbital. Drug Alcohol Depend 5:145–150

    Article  PubMed  Google Scholar 

  • Naylor H, Halliday R, Callaway E (1985) The effect of methylphenidate on information processing. Psychopharmacology 86:90–95

    Article  PubMed  Google Scholar 

  • Oborne DJ, Rogers Y (1983) Interactions of alcohol and caffeine on human reaction time. Aviat Space Environ Med 54:528–534

    PubMed  Google Scholar 

  • Pandit UA, Kothary SP, Samra SK, Domino EF, Pandit SK (1983) Physostigmine fails to reverse clinical, psychomotor or EEG effects of lorazepam. Anesth Analg 62:679–685

    PubMed  Google Scholar 

  • Peters BH, Levin HS (1977) Memory enhancement after physostigmine treatment in the amnesic syndrome. Arch Neurol 34:215–219

    PubMed  Google Scholar 

  • Poulton EC (1975) Range effects in experiments on people. Am J Psychol 88:3–32

    Google Scholar 

  • Poulton EC, Freeman PR (1966) Unwanted asymmetrical transfer effects with balanced experimental designs. Psychol Bull 66:1–8

    PubMed  Google Scholar 

  • Rapoport SI (1976) Blood brain barrier in physiology and medicine. Raven Press, New York

    Google Scholar 

  • Rizzuto AP (1987) Diazepam and its effects on psychophysiological and behavioural measures of performance. Report No AAMRL-TR-87-074, Armstrong Aerospace Medical Research Laboratory, Wright-Patterson Air Force Base, Ohio

    Google Scholar 

  • Rizzuto AP, Wilson GF, Yates RE, Palmer R (1985) Diazepam and its effects on psychophysiological measures of performance. Report No AFAMRL-TR-85-036, Air Force Aerospace Medical Research Laboratory, Wright-Patterson Air Force Base, Ohio

    Google Scholar 

  • Rundell OH, Williams HL, Lester BK (1978) Secobarbital and information processing. Percept Mot Skills 46:1255–1264

    PubMed  Google Scholar 

  • Sahakian BJ, Jones G, Levy R, Gray J, Warburton DM (1989) The effects of nicotine on attention, information processing and short-term memory in patients with dementia of the Alzheimer type. Br J Psychiatry 154:797–800

    PubMed  Google Scholar 

  • Skinner DM, Overstreet DH, Orbach J (1976) Reversal of the memory-disruptive effects of REM sleep deprivation by physostigmine. Behav Biol 18:189–198

    Article  PubMed  Google Scholar 

  • Slanska J, Safratova V, Vojechovsky M, Skala J (1971) The effect of physostigmine on the perception and consolidation phase of memory and learning in alcoholics. Acta Nerv Super 13:201–202

    Google Scholar 

  • Smith PJ, Langolf GD (1981) The use of Sternberg's memory scanning paradigm in assessing the effects of chemical exposure. Hum Factors 23:701–708

    PubMed  Google Scholar 

  • Sternberg S (1966) High-speed scanning in human memory. Science 153:652–654

    PubMed  Google Scholar 

  • Sternberg S (1967) Two operations in character recognition: some evidence from reaction time measurements. Percept Psychophys 2:45–53

    Google Scholar 

  • Sternberg S (1969a) Memory scanning: mental processes revealed by reaction time experiments. Am Sci 57:421–457

    PubMed  Google Scholar 

  • Sternberg S (1969b) The discovery of processing stages: extensions of Donders' method. Acta Psychol Attention and Performance 30:276–315

    Google Scholar 

  • Subhan Z (1984) The effects of benzodiazepines on short term memory and information processing. Psychopharmacology 1:173–181

    Google Scholar 

  • Thal LJ, Fuld PA, Masur DM, Sharpless NS, Davies P (1983) Oral physostigmine and lecithin improve memory in Alzheimer's disease. Psychopharmacol Bull 19:454–456

    PubMed  Google Scholar 

  • Tharp VK, Rundell OH, Lester BK, Williams HL (1974) Alcohol and information processing. Psychopharmacology 40:33–52

    Article  Google Scholar 

  • Warburton DM (1987) Drugs and the processing of information. In: Stahl SM, Iversen SD, Goodman EC (eds) Cognitive neurochemistry. Oxford University Press, Oxford

    Google Scholar 

  • Ward MM, Sandman CA, George JM, Shulman H (1979) MSH melanocyte stimulating hormone ACTH 4–10 in men and women: effects upon performance of an attention and memory task. Physiol Behav 22:669–674

    Article  PubMed  Google Scholar 

  • Wetherell A (1983) Atropine and diazepam actions on information processing stages in reaction time performance. Paper presented to the British Psychological Society Annual Conference, York

  • Wetherell A (1984) Physostigmine and memory. CBDE Report

  • Wetherell A (1988) Effects of physostigmine on cognitive and psychomotor performance. CBDE Report

  • Wettstein A (1983) No effect from double-blind trial of physostigmine and lecithin in Alzheimer disease. Ann Neurol 13:210–212

    Article  PubMed  Google Scholar 

  • Williams HL, Rundell OH, Smith LT (1981) Dose effects of secobarbital in a Sternberg memory scanning task. Psychopharmacology 72:161–165

    Article  PubMed  Google Scholar 

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  1. Human Factors Section, Chemical and Biological Defence Establishment, Porton Down, SP4 0JQ, Salisbury, UK

    Anthony Wetherell

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Wetherell, A. Effects of physostigmine on stimulus encoding in a memory-scanning task. Psychopharmacology 109, 198–202 (1992). https://doi.org/10.1007/BF02245500

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  • DOI: https://doi.org/10.1007/BF02245500

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