Abstract
A theory of acute tolerance to alcohol is proposed that includes two assumptions: 1) acute tolerance is a linear process with time, and 2) the slope of the line is a measure of the magnitude of the acute tolerance effect. Evidence that supports the validity of the theory is presented both from studies in which blood alcohol level (BAL) was manipulated experimentally and from studies based on the one-dose method that is common in human research. The slope of the acute tolerance line defined by this theory is a measure of the-percent decrement in maximum alcohol effect per unit time. Thus, quantitative comparisons can be made of acute tolerance effects obtained under different environmental conditions or experimental treatments, including comparisons of different drugs. Limitations of the proposed theory and the relation of this theory to other theories of tolerance to alcohol are discussed.
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References
Baker TB, Tiffany ST (1985) Morphine tolerance as habituation. Psychol Rev 92:78–108
Ekman G, Frankenhaeuser M, Goldberg L, Bjerver K, Järpe G, Myrsten A-L (1963) Effects of alcohol intake on subjective and objective variables over a five-hour period. Psychopharmacologia 4:28–38
Ekman G, Frankenhaeuser M, Goldberg L, Hagdahl R, Myrsten, A-L (1964) Subjective and objective effects of alcohol as functions of dosage and time. Psychopharmacologia 6:399–409
Ellinwood EH Jr, Linnoila M, Easler ME, Molter DW (1983) Profile of acute tolerance to three sedative anxiolytics. Psychopharmacology 79:137–141
Goldberg L (1943) Quantitative studies on alcohol tolerance in man. Acta Physiol Scand 5 [Suppl 16]: 1–128
Grieve SJ, Littleton JM (1979) The rapid development of functional tolerance to ethanol by mice. J Pharm Pharmacol 31:605–610
Grieve SJ, Griffiths PJ, Littleton JM (1979) Genetic influences on the rate of development of ethanol tolerance and the ethanol physical withdrawal syndrome in mice. Drug Alcohol Depend 4:77–86
Hays WL (1963) Statistics for psychologists. Holt, Rinehart and Winston, New York
Hurst PM, Bagley SK (1972) Acute adaptation to the effects of alcohol. Q J Stud Alcohol 33:358–378
Jellinek EM (1960) The disease concept of alcoholism. Hillhouse Press, New Brunswick, N.J.
Kalant H, LeBlanc AE, Gibbins RJ (1971) Tolerance to, and dependence on, some non-opiate psychotropic drugs. Pharmacol Rev 23:135–191
Kalant H, LeBlanc AE, Gibbins RJ, Wilson A (1978) Accelerated development of tolerance during repeated cycles of ethanol exposure. Psychopharmacology 60:59–65
Kaplan HL, Sellers EM, Hamilton C, Naranjo CA, Dorian P (1985) Is there acute tolerance to alcohol at steady state? J Stud Alcohol 46:253–256
Kelly M, Myrsten A-L, Neri A, Rydberg U (1970) Effects and after-effects of alcohol on physiological and psychological functions in man — a controlled study. Blutalkohol 7:422–436
Lê AD, Kalant H (1992) Influence of intoxicated practice on the development of acute tolerance. Psychopharmacology 106:572–576
LeBlanc AE, Kalant H, Gibbins RJ (1975) Acute tolerance to ethanol in the rat. Psychopharmacologia 41:43–46
Maynert EW, Klingman GI (1960) Acute tolerance to intravenous anesthetics in dogs. J Pharmacol Exp Ther, 128:192–200
Mellanby E (1919) Alcohol: its absorption into and disappearance from the blood under different conditions. Medical Research Committee, Special report series No. 31, London
Moskowitz H, Burns M (1976) Effects of rate of drinking on human performance. J Stud Alcohol 37:598–605
Myrsten A-L, Hollstedt C, Holmberg N (1975) Alcohol-induced changes in mood and activation in males and females. Scand J Psychol 16:303–310
Myrsten A-L, Lamble R, Frankenhaeuser M, Lundberg U (1979) Interaction of alcohol and reward in an achievement situation. Psychopharmacology 62:211–215
Portans I, White JM, Staiger PK (1989) Acute tolerance to alcohol: changes in subjective effects among social drinkers. Psychopharmacology 97:365–369
Radlow R, Hurst PM (1985) Temporal relations between blood alcohol concentration and alcohol effect: an experiment with human subjects. Psychopharmacology 85:260–266
Radlow R, Rimmele CT (1989) Effects of fast and slow drinking on humans. Alcohol Clin Exp Res 13:340
Rimmele CT (1984) The effect of acute tolerance and rate of alcohol consumption on impairment. MS thesis, San Diego State University, San Diego, Ca.
Siegel S, Krank MD, Hinson RE (1988) Anticipation of pharmacological and nonpharmacological events: classical conditioning and addictive behavior. In: Peele S (ed) Visions of addiction. D.C. Heath, Lexington, Mass., pp 85–116
Vogel-Sprott M (1979) Acute recovery and tolerance to low doses of alcohol. Psychopharmacology 61:287–291
Vogel-Sprott M (1992) Alcohol tolerance and social drinking: learning the consequences. Guilford Press, New York
Vogel-Sprott M, Sdao-Jarvie K (1989) Learning alcohol tolerance: the contribution of response expectancies. Psychopharmacology 98:289–296
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Radlow, R. A quantitative theory of acute tolerance to alcohol. Psychopharmacology 114, 1–8 (1994). https://doi.org/10.1007/BF02245438
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DOI: https://doi.org/10.1007/BF02245438