Abstract
Thirty-eight subjects who met criteria for the DSM-III-R diagnosis late luteal phase dysphoric disorder (LLPDD) were compared with 18 controls in 5-HT uptake kinetics of the platelets in the premenstrual (day 26) as well as in the postmenstrual phase (day 4) of the cycle. Furthermore, 5-hydroxytryptophan (5-HTP) was administered to LLPDD patients and controls in both phases of the cycle, to investigate pituitary sensitivity for serotonin. Plasma samples for the measurement of cortisol and β-endorphin were taken before and after oral administration of 200 mg 5-HTP, and considered as an index of pituitary-adrenal function. LLPDD was not associated with a lower platelet 5-HT uptake and content in the premenstrual phase of the cycle, compared with the postmenstrual phase. Patients appeared not to be different from controls in 5-HT uptake kinetics of platelets in the premenstrual phase of the cycle. No main differences were observed between LLPDD patients and controls in their ability to respond with secretion of cortisol and β-endorphin to 5-HTP stimulation, either in the premenstrual, or in the postmenstrual phase. This observation could not be attributed to differences in 5-HTP metabolism. The findings of the present study do not support a specific role for 5-HT in the pathophysiology LLPDD.
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References
American Psychiatric Association (1987) Diagnostic and statistical manual of mental disorders, 3rd edn revised (DSM-III-R). Washington, DC
Arts CJM, Koppeschaar HPF, Veenman W, Thijssen JHH (1985) A direct radioimmunoassay for the determinaton of adrenocorticotropic hormone (ACTH) and a clinical evaluation. Ann Clin Biochem 22:247–256
Åsberg MP, Thoren L, Traskman L, Bertilson L, Ringberger VA (1976) Serotonin depression — a biochemical subgroup within affective disorders? Science 191:478–480
Ashby CR, Carr LA, Cook CL, Steptoe MM, Franks DD (1988) Alteration of platelet serotonergic mechanisms and monoamine oxidase activity in premenstrual syndrome. Biol Psychiatry 24:225–233
Bancroft J, Cook A, Davidson D, Bennie J, Goodwin G (1991) Blunting of neuroendocrine responses to infusion ofl-tryptophan in women with perimenstrual mood change. Psychol Med 21:305–312
Blume E (1983) Methodological difficulties plague PMS research. JAMA 249:2866
Den Boer JA, Westenberg HGM (1990a) Serotonin function in panic disorder: a double blind placebo controlled study with fluvoxamin and ritanserin. Psychopharmacology 102:85–94
Den Boer JA, Westenberg HGM (1990b) Behavioral, neuroendocrine, and biochemical effects of 5-hydroxytryptophan administration in panic disorder. Psychiatry Res 31:267–278
Gispen-De Wied CC, Westenberg HGM, Thijssen JHH, Van Ree JM (1987) The dexamethason and cortisol suppression test in depression: beta-endorphin as a useful marker? Psychoneuroendocrinology 12:355–366
Gispen-De Wied CC, Westenberg, HGM, Thijssen JHH, Van Ree JM (1991) 5-Hydroxytryptophan-induced stimulation of the pituitary-adrenal system in depressed patients and healthy subjects. In: Gispen-De Wied CC (ed) The hypothalamo-pituitary adrenal axis in depression. Thesis, University of Utrecht, pp 85–92
Haskett RF (1987) Premenstrual dysphoric disorder: evaluation, pathophysiology and treatment. Prog Neuropsychopharmacol Biol Psychiatry 11:129–135
Labrum AH (1983) Hypothalamic, pineal and pituitary factors in the premenstrual syndrome. J Reprod Med: 438–445
Malmgren R, Collins A, Nilsson CG (1987) Platelet serotonin uptake and effects of vitamin B6-treatment in premenstrual tension. Neuropsychobiology 18:83–88
Meltzer HY, Arora RC, Baber R, Tricou BJ (1981) Serotonin uptake in blood platelets of psychiatric patients. Arch Gen Psychiatry 38:1322–1326
Meltzer HY, Umberkoman-Wiita B, Robertson A, Tricon BJ, Lowy M, Perline R (1984) Effect of 5-HTP on serum cortisol levels in major affective disorders. I. Enhanced response in depression and mania. Arch Gen Psychiatry 41:366–374
Moos RH (1985) Perimenstrual symptoms: a manual and overview of research with the Menstrual Distress Questionnaire. Department of Psychiatry and Behavioral Sciences, Palo Alto, California
Myung A, Lee J, Nash F, Barnes M, Meltzer HY (1991) Inhibitory effect of ritanserin on the 5-hydroxytryptophan-mediated cortisol, ACTH and prolactin secretion in humans. Psychopharmacology 103:258–264
Rabin DS, Schmidt PJ, Campbell G, Gold PW, Jensvold M, Rubinow DR, Chrousos GP (1990) Hypothalamic-pituitary-adrenal function in patients with the premenstrual syndrome. J Clin Endocrinol Metab 71:1158–1162
Rapkin AJ, Edelmuth E, Chang LC, Reading AE, McGuire MT, Su TP (1987) Whole-blood serotonin in premenstrual syndrome. Obstet Gynecol 70:533–537
Rapkin AJ, Chang LC, Reading AE (1989) Tryptophan loading test in premenstrual syndrome. J Obstet Gynecol 10:140–144
Roy-Byrne PP, Hoban CM, Rubinow DR (1987) The relationship of menstrually related mood disorders to psychiatric illness. Clin Obstet Gynecol 30:386–395
Shopsin B, Feiner NF (1984) Serotonin and depression. Adv Biol Psychiatry 14:1–11
Tam WYK, Chan MY, Lee PHK (1985) The menstrual cycle and platelet 5-HT uptake. Psychosom Med 47:352–362
Taylor DL, Matthew RJ, Weinman ML (1984) Serotonin levels and platelet uptake during premenstrual tension. Neuropsychobiology 12:16–18
Thijssen JHH, van den Berg JHM, Adlercreutz J (1980) The determination of cortisol in human plasma: evaluation and comparison of seven assays. Clin Chim Acta 100:39–46
Tuomisto J, Tukiainen E, Ahlfors UG (1979) Decreased uptake of hydroxy-tryptamine in blood platelets from patients with endogenous depression. Psychopharmacology 65:141
Van Praag HM (1988) Serotonin disturbances in psychiatric disorders. Functional versus nosological interpretation. Adv Biol Psychiatry 17:52–57
Van Praag HM, Lemus C, Kahn RS (1987) Hormonal probes of central serotonergic activity: do they really exist? Biol Psychiatry 22:86–98
Van der Ploeg HM (1986) Menstruatie Klachten Vragenlijst (Dutch adaptation of the Menstrual Distress Questionnaire). Swets en Zeitlinger, Lisse
Westenberg HGM, Den Boer JA (1988) Clinical and biochemical effects of selective serotonin-uptake inhibitors in anxiety disorders. Adv Biol Psychiatry 17:84–99
Westenberg HGM, Verhoeven WMA (1988) CSF monoamine metabolites in patients and controls: support for a biomodal distribution in major affective disorders. Acta Psychiatr Scand 78:541–549
Westenberg HGM, Van Praag HM, De Jong JTVM, Thyssen JHH (1982a) Postsynaptic serotonergic activity in depressive patients: evaluation of the neuroendocrine strategy. Psychiatry Res 7:361–371
Westenberg HGM, Gerritsen TW, Meyer BA, Van Praag HM (1982b) Kinetics ofl-5-hydroxytryptophan in healthy subjects. Psychiatry Res 7:373–385
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Veeninga, A.T., Westenberg, H.G.M. Serotonergic function and late luteal phase dysphoric disorder. Psychopharmacology 108, 153–158 (1992). https://doi.org/10.1007/BF02245301
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DOI: https://doi.org/10.1007/BF02245301