Psychopharmacology

, Volume 118, Issue 1, pp 42–51 | Cite as

Competitive and uncompetitiveN-methyl-d-aspartate antagonist discriminations in pigeons: CGS 19755 and phencyclidine

  • Scott P. Baron
  • James H. Woods
Original Investigation

Abstract

The purpose of the present studies was to examine representative uncompetitive and competitive NMDA antagonists, as well as the glycine/NMDA antagonist, HA 966, in pigeons trained to discriminate either PCP or CGS 19755 from saline. Separate groups of pigeons were trained to discriminate either the uncompetitive, phencyclidine (PCP; 0.32 and 1.0 mg/kg, IM), or the competitive, CGS 19755 (cis-4-phosphonomethyl-2-piperidine-carboxylic acid; 1.8 mg/kg, IM), NMDA antagonists from saline. Uncompetitive and competitive NMDA antagonists were examined in generalization studies, as were the racemate and the (+) and (−) stereoisomers of HA 966 (3-amino-1-hydroxypyrrolid-2-one). Dizocilpine (MK 801) was fully generalized to PCP but not to CGS 19755. All competitive NMDA antagonists tested were fully generalized to CGS 19755, but not to PCP. The competitive antagonists, however, produced >50% PCP-appropriate responding. The (+) isomer of HA 966 was fully generalized by three of four pigeons discriminating PCP (1.0 mg/kg) or CGS 19755, whereas the racemate and the (−) isomer produced <40% drugappropriate responding in either group. Neither NMDA, morphine, nor pentobarbital produced >10% drug-appropriate responding in either discrimination group. The competitive antagonists tended to produce peak drug-appropriate responding at times greater than 60 min after administration, whereas uncompetitive antagonists produced peak drug-appropriate responding at earlier times. HA 966 also had a relatively slow onset of action as compared to PCP. These results suggest that antagonists acting at different modulatory sites of the NMDA receptor complex produce similar, but not identical, discriminative stimuli.

Key words

Drug discrimination NMDA antagonists Phencyclidine CGS 19755 Pigeons 

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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • Scott P. Baron
    • 1
    • 2
  • James H. Woods
    • 3
  1. 1.Department of PsychologyUniversity of MichiganAnn ArborUSA
  2. 2.Department of Pharmacology and Experimental TherapeuticsLouisiana State University Medical CenterNew OrleansUSA
  3. 3.Department of PharmacologyUniversity of MichiganAnn ArborUSA

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