, Volume 107, Issue 2–3, pp 453–456 | Cite as

Haloperidol reduces ethanol-induced motor activity stimulation but not conditioned place preference

  • Fred O. Risinger
  • Shelly D. Dickinson
  • Christopher L. Cunningham
Rapid Communications


This experiment examined the impact of a dopamine receptor blocker on ethanol's rewarding effect in a place conditioning paradigm. DBA/2J mice received four pairings of a tactile stimulus with ethanol (2 g/kg, IP), haloperidol (0.1 mg/kg, IP) + ethanol, or haloperidol alone. A different stimulus was paired with saline. Ethanol produced increases in locomotor activity that were reduced by haloperidol. However, conditioned preference for the ethanol-paired stimulus was not affected by haloperidol. Haloperidol alone decreased locomotor activity during conditioning and produced a place aversion. These results indicate a dissociation of ethanol's activating and rewarding effects. Moreover, they suggest that ethanol's ability to induce conditioned place preference is mediated by nondopaminergic mechanisms.

Key words

Haloperidol Ethanol Conditioned place aversion Conditioned place preference Inbred mice (DBA/2J) Locomotor activity Reward Dopamine system 


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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • Fred O. Risinger
    • 1
  • Shelly D. Dickinson
    • 1
  • Christopher L. Cunningham
    • 1
  1. 1.Department of Medical PsychologyThe Oregon Health Sciences UniversityPortlandUSA

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