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Psychopharmacology

, Volume 107, Issue 2–3, pp 453–456 | Cite as

Haloperidol reduces ethanol-induced motor activity stimulation but not conditioned place preference

  • Fred O. Risinger
  • Shelly D. Dickinson
  • Christopher L. Cunningham
Rapid Communications

Abstract

This experiment examined the impact of a dopamine receptor blocker on ethanol's rewarding effect in a place conditioning paradigm. DBA/2J mice received four pairings of a tactile stimulus with ethanol (2 g/kg, IP), haloperidol (0.1 mg/kg, IP) + ethanol, or haloperidol alone. A different stimulus was paired with saline. Ethanol produced increases in locomotor activity that were reduced by haloperidol. However, conditioned preference for the ethanol-paired stimulus was not affected by haloperidol. Haloperidol alone decreased locomotor activity during conditioning and produced a place aversion. These results indicate a dissociation of ethanol's activating and rewarding effects. Moreover, they suggest that ethanol's ability to induce conditioned place preference is mediated by nondopaminergic mechanisms.

Key words

Haloperidol Ethanol Conditioned place aversion Conditioned place preference Inbred mice (DBA/2J) Locomotor activity Reward Dopamine system 

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References

  1. Bozarth MA (1990) Evidence for the rewarding effects of ethanol using the conditioned place preference method. Pharmacol Biochem Behav 35:485–487Google Scholar
  2. Carr GD, Pibiger HC, Phillips AG (1989) Conditioned place preference as a measure of drug reward. In: Liebman JM, Cooper SJ (eds) Neuropharmacological basis of reward. Oxford, New York, pp 264–319Google Scholar
  3. Cunningham, CL (1992) Pavlovian drug conditioning. In: van Haaren P (ed) Methods in behavioral pharmacology. Elsevier, AmsterdamGoogle Scholar
  4. Cunningham CL, Noble D (1991) Conditioning of activity and place preference by ethanol. Alcohol Clin Exp Res 15:320Google Scholar
  5. Cunningham CL, Prather LK (1990) Ethanol-induced conditioned place preference in mice: Role of conditioning trial duration. Soc Neurosci Abstr 16:755Google Scholar
  6. Cunningham CL, Hallett CL, Niehus DR, Hunter JS, Nouth L, Risinger FO (1991) Assessment of ethanol's hedonic effects in mice selectively bred for sensitivity to ethanol-induced hypothermia. Psychopharmacology 105:84–92Google Scholar
  7. Cunningham CL, Niehus DR, Malott DH, Prather LK (1992) Genetic differences in the rewarding and activating effects of morphine and ethanol. Psychopharmacology 107:385–393Google Scholar
  8. Dworkin SI, Smith JE (1988) Molecular mechanisms of drug reinforcement-current status. In: Harris LS (ed) Problems of drug dependence. Rockville, MD: NIDA Research Monograph No. 90, pp 266–274Google Scholar
  9. Hiroi N, White NM (1990) The reserpine-sensitive dopamine pool mediates (+)-amphetamine-conditioned reward in the place preference paradigm. Brain Res 510:33–42CrossRefPubMedGoogle Scholar
  10. Hoffman DC (1989) The use of place conditioning in studying the neuropharmacology of drug reinforcement. Brain Res Bull 23:373–387CrossRefPubMedGoogle Scholar
  11. Pfeffer AO, Samson HH (1986) Effect of pimozide on home cage ethanol drinking in the rat: dependence on drinking session length. Drug Alcohol Depend 17:47–55CrossRefPubMedGoogle Scholar
  12. Pfeffer AO, Samson HH (1988) Haloperidol and apomorphine effects on ethanol reinforcement in free feeding rats. Pharmacol Biochem Behav 29:343–350CrossRefPubMedGoogle Scholar
  13. Reid LD, Hunter GA, Beaman CM, Hubbell CL (1985) Toward understanding ethanol's capacity to be reinforcing: a conditioned place preference following injections of ethanol. Pharmacol Biochem Behav 22:483–487Google Scholar
  14. Risinger FO, Cunningham CL (1992) Ethanol produces rapid biphasic hedonic effects. Ann NY Acad Sci (in press)Google Scholar
  15. Risinger FO, Malott DH, Riley AL, Cunningham CL (1991) Effect of Ro 15-4513 on ethanol-induced conditioned place preference. Alcohol Clin Exp Res 15:314Google Scholar
  16. Sherman JE, Jorenby DE, Baker TB (1988) Classical conditioning with alcohol: Acquired preferences and aversions, tolerance, and urges/craving. In: Chaudron CD, Wilkinson DA (eds) Theories on alcoholism. Addiction Research Foundation, Toronto, pp 173–237Google Scholar
  17. Stewart RB, Grupp LA (1981) An investigation of the interaction between the reinforcing properties of food and ethanol using the place preference paradigm. Prog Neuropsychopharmacol 5:609–613Google Scholar
  18. Swerdlow NR, Gilbert D, Koob GF (1989) Conditioned drug effects on spatial preference: Critical evaluation. In: Boulton AA, Baker GB, Greenshaw AJ (eds) Psychopharmacology (Neuromethods, vol 13). Humana, Clifton NJ, pp 399–446Google Scholar
  19. Wise RA, Bozarth MA (1987) A psychomotor stimulant theory of addiction. Psychol Rev 94:469–492CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • Fred O. Risinger
    • 1
  • Shelly D. Dickinson
    • 1
  • Christopher L. Cunningham
    • 1
  1. 1.Department of Medical PsychologyThe Oregon Health Sciences UniversityPortlandUSA

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