Abstract
Fentanyl is a mu opiate agonist which is occasionally abused by medical personnel who have ready access to the drug. We examined in healthy volunteers (N=13) the subjective and psychomotor-impairing effects of intravenous fentanyl (0–100 µg/70 kg). A randomized, placebo-controlled, crossover design was used in which subjects were injected with 0, 25 (N=6), 50 and 100 µg/70 kg fentanyl in a double-blind fashion. Subjects completed several questionnaires commonly used in abuse liability testing studies before drug injection and at periodic intervals for up to 3 h after drug injection. Subjects also completed several psychomotor tests at these times. Some aspects of psychomotor functioning (e.g., eye-hand coordination) were impaired by fentanyl. Fentanyl produced dose-related increases in ratings of “high” and “sedated,” but also tended to produce dysphoria and somatic symptomatology. Most subjects reported liking the effects of the two higher doses of fentanyl for at least a brief time after injection, but they varied widely in their liking ratings across the 3-h post-drug injection period. Despite the transient increases in liking ratings, fentanyl did not increase scores on a widely-used measure of drug-induced euphoria (morphine-benzedrine group scale of the Addiction Research Center Inventory). The present results suggest that some medical personnel who experiment with fentanyl may like it, and thus be at increased risk for abusing the drug in the future.
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References
American Psychiatric Association (1987) Diagnostic and statistical manual of mental disorders. American Psychiatric Association, Washington DC
Chait LD, Fischman MW, Schuster CR (1985) “Hangover” effects the morning after marijuana smoking. Drug Alcohol Depend 15:229–238
de Wit H, Griffiths RR (1991) Testing the abuse liability of anxiolytic and hypnotic drugs in humans. Drug Alcohol Depend 28:83–111
Evans SM, Funderburk FR, Griffiths RR (1990) Zolpidem and triazolam in humans: Behavioral and subjective effects and abuse liability. J Pharmacol Exp Ther 255:1246–1255
Fraser HF, van Horn GD, Wolbach AB, Isbell H (1961) Methods for evaluating addiction liability. (A) “Attitude” of opiate addicts toward opiate-like drugs, (B) A short-term “direct” addiction test. J Pharmacol Exp Ther 133:371–387
Ghoneim MM, Mewaldt SP, Thatcher JW (1975) The effect of diazepam and fentanyl on mental, psychomotor and electroencephalographic functions and their rate of recovery. Psychopharmacologia 44:61–66
Gravenstein JS, Smith GM, Sphire R, Isaacs JP, Beecher HK (1956) Dihydocodeine: further development in measurement of analgesic power and appraisal of psychologic side effects of analgesic agents. New Engl J Med 254:877–885
Haertzen CA (1966) Development of scales based on patterns of drug effects, using the Addiction Research Center Inventory (ARCI). Psychol Rep 18:163–194
Hannington-Kiff JG (1970) Measurement of recovery from outpatient general anaesthesia with a simple ocular test. Br Med J 3:132–135
Hoehe M (1988) Influence of the menstrual cycle on neuroendocrine and behavioral responses to an opiate agonist in humans: preliminary results. Psychoneuroendocrinology 13:339–344
Hoehe M, Duka T, Doenicke A (1988) Human studies on the μ opiate receptor agonist fentanyl: neuroendocrine and behavioral responses. Psychoneuroendocrinology 13:397–408
Jarvik LF, Simpson JH, Guthrie D, Liston EH (1981) Morphine, experimental pain, and psychological reactions. Psychopharmacology 75:124–131
Jasinski DR (1977) Assessment of the abuse potential of morphine-like drugs (methods in man). In: Martin WR (ed) Handbook of experimental pharmacology, vol 45/1. Springer, Berlin Heidelberg New York, pp 197–258
Jasinski DR, Preston KL (1985) Assessment of dezocine for morphine-like subjective effects and miosis. Clin Pharmacol Ther 38:544–548
Jasinski DR, Johnson RE, Henningfield JE (1984) Abuse liability assessment in human subjects. TIPS 5:196–200
Kirby KC, Stitzer ML, Heishman SJ (1990) Acute opioid physical dependence in humans: effect of varying the morphine-naloxone interval. J Pharmacol Exp Ther 255:730–737
Kornetsky C, Humphries O, Evarts EV (1957) Comparison of psychological effects of certain centrally acting drugs in man. Arch Neurol Psychiatry 77:318–324
Lasagna L, von Felsinger JM, Beecher JK (1955) Drug-induced mood changes in man. JAMA 157:1006–1020
Linnoila M, Hakkinen S (1974) Effects of diazepam and codeine, alone and in combination with alcohol, on simulated driving. Clin Pharmacol Ther 15:368–373
MacAuliffe WE (1975) A second look at first effects: the subjective effects of opiates on nonaddicts. J Drug Issues 5:369–399
Manner T, Kanto J, Salonen M (1987) Simple devices in differentiating the effects of buprenorphine and fentanyl in healthy volunteers. Eur J Clin Pharmacol 31:673–676
Martin WR, Sloan JW, Sapira JD, Jasinski DR (1971) Physiologic, subjective, and behavioral effects of amphetamine, methamphetamine, ephedrine, phenmetrazine, and methylphenidate in man. Clin Pharmacol Ther 12:245–258
Matejcek M, Pokorny R, Ferber G, Klee H (1988) Effect of morphine on the electroencephalogram and other physiological and behavioral parameters. Neuropsychobiology 19:202–211
Matussek N, Hoehe M (1989) Investigations with the specific muopiate receptor agonist fentanyl in depressive patients: growth hormone, prolactin, cortisol, noradrenaline and euphoric responses. Neuropsychobiology 21:1–8
Neil A (1984) Affinities of some common opioid analgesics towards four binding sites in mouse brain. Naunyn-Schmiedberg's Arch Pharmacol 328:24–29
Nuotto EJ, Korttila KT (1991) Evaluation of a new computerized psychomotor test battery: effects of alcohol. Pharmacol Toxicol 68:360–365
Posner J (1984) A modified submaximal effort tourniquet test for evaluation of analgesics in healthy volunteers. Pain 19:143–151
Posner J, Telekes A, Crowley D, Phillipson R, Peck AW (1985) Effects of an opiate on cold-induced pain and the CNS in healthy volunteers. Pain 23:73–82
Preston KL, Bigelow GE, Liebson IA (1989) Antagonist effects of nalbuphine in opioid-dependent human volunteers. J Pharmacol Exp Ther 248:929–937
Preston KL, Jasinski DR, Testa M (1991) Abuse potential and pharmacological comparison of tramadol and morphine. Drug Alcohol Depend 27:7–17
Romagnoli A, Keats AS (1984) Ceiling respiratory depression by dezocine. Clin Pharmacol Ther 35:367–373
Saarialho-Kere U, Mattila MJ, Seppala T (1986) Pentazocine and codeine: effects on human performance and mood and interactions with diazepam. Med Biol 64:293–299
Saarialho-Kere U, Mattila MJ, Paloheimo M, Seppala T (1987) Psychomotor, respiratory and neuroendocrinological effects of buprenorphine and amitriptyline in healthy volunteers. Eur J Clin Pharmacol 33:139–146
Saarialho-Kere U, Julkunen H, Mattila MJ, Seppala T (1988) Psychomotor performance of patients with rheumatoid arthritis: cross-over comparison of dextropropoxyphene, dextropropoxyphene plus amitriptyline, indomethacin, and placebo. Pharmacol Toxicol 63:286–292
Saarialho-Kere U, Mattila MJ, Seppala T (1989) Psychomotor, respiratory and neuroendocrinological effects of a μ-opioid receptor agonist (oxycodone) in healthy volunteers. Pharmacol Toxicol 65:252–257
Scamman Fl, Ghoneim MM, Korttila K (1984) Ventilatory and mental effects of alfentanil and fentanyl. Acta Anaesthesiol Scand 28:63–67
Silsby HD, Kruzich DJ, Hawkins MR (1984) Fentanyl citrate abuse among health care professionals. Milit Med 149:227–228
Smith GM, Beecher HK (1962) Subjective effects of heroin and morphine in normal subjects. J Pharmacol Exp Ther 136:47–52
Ward CF, Ward GC, Saidman LJ (1983) Drug abuse in anesthesia training programs: a survey: 1970 through 1980. JAMA 250:922–925
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Zacny, J.P., Lance Lichtor, J., Zaragoza, J.G. et al. Subjective and behavioral responses to intravenous fentanyl in healthy volunteers. Psychopharmacology 107, 319–326 (1992). https://doi.org/10.1007/BF02245155
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DOI: https://doi.org/10.1007/BF02245155