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Reinforcing and subjective effects of oral Δ9-THC and smoked marijuana in humans

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Abstract

The reinforcing and subjective effects of oral delta-9-tetrahydrocannabinol (THC) and smoked marijuana were studied in two groups of regular marijuana users. One group (N=10) was tested with smoked marijuana and the other (N=11) with oral THC. Reinforcing effects were measured with a discrete-trial choice procedure which allowed subjects to choose between the self-administration of active drug or placebo on two independent occasions. Subjective effects and heart rate were measured before and after drug administration. Smoked active marijuana was chosen over placebo on both choice occasions by all subjects. Similarly, oral THC was chosen over placebo on both occasions by all but one subject. Both active drug treatments produced qualitatively and quantitatively similar subjective effects, and both significantly increased heart rate, although the time course of effects differed substantially between the two treatments. The results demonstrate that both smoked marijuana and oral THC can serve as positive reinforcers in human subjects under laboratory conditions. The experimental paradigm used here should prove useful for identifying factors that influence the self-administration of marijuana and other cannabinoids by humans.

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References

  • Busto U, Sellers EM (1986) Pharmacokinetic determinants of drug abuse and dependence. A conceptual perspective. Clin Pharmacokinet 11:144–153

    PubMed  Google Scholar 

  • Chait LD (1989) Delta-9-tetrahydrocannabinol content and human marijuana self-administration. Psychopharmacology 98:51–55

    Google Scholar 

  • Chait LD, Griffiths RR (1982) Smoking behavior and tobacco smoke intake: response of smokers to shortened cigarettes. Clin Pharmacol Ther 32:90–97

    PubMed  Google Scholar 

  • Chait LD, Pierri J (1989) Some physical characteristics of NIDA marijuana cigarettes. Addict Behav 14:61–67

    Article  PubMed  Google Scholar 

  • Chait LD, Fischman MW, Schuster CR (1985) “Hangover” effects the morning after marijuana smoking. Drug Alcohol Depend 15:229–238

    Article  PubMed  Google Scholar 

  • Chait LD, Uhlenhuth EH, Johanson CE (1987) Reinforcing and subjective effects of several anorectics in normal human volunteers. J Pharmacol Exp Ther 242:777–783

    PubMed  Google Scholar 

  • Chait LD, Evans SM, Grant KA, Kamien JB, Johanson CE, Schuster CR (1988) Discriminative stimulus and subjective effects of smoked marijuana in humans. Psychopharmacology 94:206–212

    Google Scholar 

  • Cone EJ, Johnson RE, Paul BD, Mell LD, Mitchell J (1988) Marijuana-laced brownies: behavioral effects, physiological effects, and urinalysis in humans following ingestion. J Analyt Toxicol 12:169–175

    Google Scholar 

  • Cousens K, DiMascio A (1973) (-)-delta-9-THC as an hypnotic. An experimental study of three dose levels. Psychopharmacologia 33:355–364

    Google Scholar 

  • de Wit H, Uhlenhuth EH, Hedeker D, McCracken SG, Johanson CE (1986) Lack of preference for diazepam in anxious volunteers. Arch Gen Psychiatry 43:533–541

    PubMed  Google Scholar 

  • de Wit H, Uhlenhuth EH, Pierri J, Johanson CE (1987) Individual differences in behavioral and subjective responses to alcohol. Alcohol Clin Exp Res 11:52–59

    PubMed  Google Scholar 

  • de Wit H, Pierri J, Johanson CE (1989) Assessing individual differences in ethanol preference using a cumulative dosing procedure. Psychopharmacology 98:113–119

    Google Scholar 

  • Dixon WJ (ed) (1983) BMDP statistical software. University of California Press, Berkeley

    Google Scholar 

  • Downs DA, Woods JH (1974) Codeine- and cocaine-reinforced responding in rhesus monkeys: effects of dose on response rates under a fixed-ratio schedule. J Pharmacol Exp Ther 191:179–188

    PubMed  Google Scholar 

  • Fischman MW (1989) Relationship between self-reported drug effects and their reinforcing effects: studies with stimulant drugs. In: Fischman MW, Mello NK (eds) Testing for abuse liability of drugs in humans. NIDA Research Monograph 92, US Department of Health and Human Services, Rockville, MD, pp 211–230

    Google Scholar 

  • Fischman MW, Foltin RW, Nestadt G, Pearlson GD (1990) Effects of desipramine maintenance on cocaine self-administration by humans. J Pharmacol Exp Ther 253:760–770

    PubMed  Google Scholar 

  • Fligiel SEG, Venkat H, Gong H, Tashkin DP (1988) Bronchial pathology in chronic marijuana smokers: a light and electron microscopic study. J Psychoactive Drugs 20:33–42

    PubMed  Google Scholar 

  • Foltin RW, Brady JV, Fischman MW (1986) Behavioral analysis of marijuana effects on food intake in humans. Pharmacol Biochem Behav 25:577–582

    Article  PubMed  Google Scholar 

  • Foltin RW, Fischman MW, Byrne MF (1988) Effects of smoked marijuana on food intake and body weight of humans living in a residential laboratory. Appetite 11:1–14

    Article  Google Scholar 

  • Foltin RW, Fischman MW, Brady JV, Capriotti RM, Emurian CS (1989) The regularity of smoked marijuana self-administration. Pharmacol Biochem Behav 32:483–486

    Google Scholar 

  • Goldstein A, Kalant H (1990) Drug policy: striking the right balance. Science 249:1513–1521

    Google Scholar 

  • Greenberg I, Kuehnle J, Mendelson JH, Bernstein JG (1976) Effects of marijuana use on body weight and caloric intake in humans. Psychopharmacology 49:79–84

    Google Scholar 

  • Griffiths RR, Woodson PP (1988) Reinforcing effects of caffeine in humans. J Pharmacol Exp Ther 246:21–29

    PubMed  Google Scholar 

  • Griffiths RR, Bigelow GE, Liebson I (1976) Human sedative self-administration: effects of interingestion interval and dose. J Pharmacol Exp Ther 197:488–494

    PubMed  Google Scholar 

  • Haertzen CA (1974) An overview of Addiction Research Center Inventory Scales (ARCI): An appendix and manual of scales. US Government Printing Office, Washington

    Google Scholar 

  • Harris RT, Waters W, McLendon D (1974) Evaluation of reinforcing capability of delta-9-tetrahydrocannabinol in rhesus monkeys. Psychopharmacologia 37:23–29

    Article  PubMed  Google Scholar 

  • Heishman SJ, Stitzer ML, Yingling JE (1989) Effects of tetrahydrocannabinol content on marijuana smoking behavior, subjective reports, and performance. Pharmacol Biochem Behav 34:173–179

    Google Scholar 

  • Hollister LE (1971) Hunger and appetite after single doses of marihuana, alcohol, and dextroamphetamine. Clin Pharmacol Ther 12:44–49

    PubMed  Google Scholar 

  • Hollister LE, Gillespie HK (1973) delta-8- and delta-9-tetrahydrocannabinol. Comparison in man by oral and intravenous administration. Clin Pharmacol Ther 14:353–357

    PubMed  Google Scholar 

  • Jasinski DR, Henningfield JE (1989) Human abuse liability assessment by measurement of subjective and physiological effects. In: Fischman MW, Mello NK (eds) Testing for abuse liability of drugs in humans. NIDA Research Monograph 92, US Department of Health and Human Services, Rockville, MD, pp 73–100

    Google Scholar 

  • Johanson CE, Schuster CR (1975) A choice procedure for drug reinforcers: cocaine and methylphenidate in the rhesus monkey. J Pharmacol Exp Ther 193:676–688

    PubMed  Google Scholar 

  • Kato S, Wakasa Y, Yanagita T (1987) Relationship between minimum reinforcing doses and injection speed in cocaine and pentobarbital self-administration in crab-eating monkeys. Pharmacol Biochem Behav 28:407–410

    Google Scholar 

  • Leite JR, Carlini EA (1974) Failure to obtain “cannabis-directed behavior” and abstinence syndrome in rats chronically treated with cannabis sativa extracts. Psychopharmacologia 36:133–145

    Google Scholar 

  • McNair DM, Lorr M, Droppleman LF (1971) Manual for the Profile of Mood States. Educational and Industrial Testing Service, San Diego

    Google Scholar 

  • Mello NK, Mendelson JH (1985) Operant acquisition of marihuana by women. J Pharmacol Exp Ther 235:162–171

    PubMed  Google Scholar 

  • Mello NK, Mendelson JH, Kuehnle JC, Sellers ML (1978) Human polydrug use: marijuana and alcohol. J Pharmacol Exp Ther 207:922–935

    PubMed  Google Scholar 

  • Mendelson JH, Mello NK (1984) Reinforcing properties of oral delta-9-tetrahydrocannabinol, smoked marijuana, and nabilone: influence of previous marijuana use. Psychopharmacology 83:351–356

    Google Scholar 

  • Mendelson JH, Kuehnle JC, Greenberg I, Mello NK (1976) Operant acquisition of marihuana in man. J Pharmacol Exp Ther 198:42–53

    PubMed  Google Scholar 

  • Ohlsson A, Lindgren J-E, Wahlen A, Agurell S, Hollister LE, Gillespie HK (1980) Plasma delta-9-tetrahydrocannabinol concentrations and clinical effects after oral and intravenous administration and smoking. Clin Pharmacol Ther 28:409–416

    PubMed  Google Scholar 

  • Parrott AC, Hindmarch I (1980) The Leeds Sleep Evaluation Questionnaire in psychopharmacological investigations-a review. Psychopharmacology 71:173–179

    Article  Google Scholar 

  • Stitzer ML, McCaul ME, Bigelow GE, Liebson I (1983) Oral methadone self-administration: effects of dose and alternative reinforcers. Clin Pharmacol Ther 34:29–35

    PubMed  Google Scholar 

  • Takahashi RN, Singer G (1979) Self-administration of delta-9-tetrahydrocannabinol by rats. Pharmacol Biochem Behav 11:737–740

    Google Scholar 

  • van Ree JM, Slangen JL, de Wied D (1978) Intravenous self-administration of drugs in rats. J Pharmacol Exp Ther 204:547–557

    PubMed  Google Scholar 

  • Wu T-C, Tashkin DP, Djahed B, Rose JE (1988) Pulmonary hazards of smoking marijuana as compared with tobacco. N Engl J Med 318:347–351

    PubMed  Google Scholar 

  • Zacny JP, Chait LD (1991) Response to marijuana as a function of potency and breathhold duration. Psychopharmacology 103:223–226

    Google Scholar 

  • Zacny JP, de Wit H (1989) Effects of food deprivation on responses to marijuana in humans. Behav Pharmacol 1:177–185

    Google Scholar 

Download references

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  1. Drug Abuse Research Center, Department of Psychiatry, The Pritzker School of Medicine, The University of Chicago, 5841 South Maryland Avenue, 60637, Chicago, IL, USA

    L. D. Chait & James P. Zacny

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  1. L. D. Chait
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  2. James P. Zacny
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Chait, L.D., Zacny, J.P. Reinforcing and subjective effects of oral Δ9-THC and smoked marijuana in humans. Psychopharmacology 107, 255–262 (1992). https://doi.org/10.1007/BF02245145

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  • DOI: https://doi.org/10.1007/BF02245145

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