Differential changes in serotonin 5-HT1A and 5-HT2 receptor binding in patients with chronic schizophrenia

Abstract

Serotonin 5-HT1A and 5-HT2 receptors were examined in the postmortem brains of controls and patients with chronic schizophrenia. In the prefrontal cortex from patients with schizophrenia, 5-HT1A receptor binding was increased, while 5-HT2 receptor binding was decreased, when compared to controls. The increased 5-HT1A receptor binding or the decreased 5-HT2 receptor binding was observed in both the patients who had been medicated with neuroleptics at time of death and those who had not, at least 2 months prior to death. Thus, abnormalities of 5-HT receptor subtypes seem to exist in the brains of patients with chronic schizophrenia. 5-HT related agents might be beneficial for the treatment of schizophrenia.

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Correspondence to Naoki Nishino.

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Hashimoto, T., Kitamura, N., Kajimoto, Y. et al. Differential changes in serotonin 5-HT1A and 5-HT2 receptor binding in patients with chronic schizophrenia. Psychopharmacology 112, S35–S39 (1993). https://doi.org/10.1007/BF02245005

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Key words

  • Serotonin
  • Serotonin1A(5-HT1A) receptor
  • Serotonin2(5-HT2) receptor
  • Schizophrenia
  • Postmortem brain