, Volume 112, Supplement 1, pp S35–S39 | Cite as

Differential changes in serotonin 5-HT1A and 5-HT2 receptor binding in patients with chronic schizophrenia

  • Takeshi Hashimoto
  • Noboru Kitamura
  • Yasuo Kajimoto
  • Yutaka Shirai
  • Osamu Shirakawa
  • Tatsuo Mita
  • Naoki Nishino
  • Chikako Tanaka


Serotonin 5-HT1A and 5-HT2 receptors were examined in the postmortem brains of controls and patients with chronic schizophrenia. In the prefrontal cortex from patients with schizophrenia, 5-HT1A receptor binding was increased, while 5-HT2 receptor binding was decreased, when compared to controls. The increased 5-HT1A receptor binding or the decreased 5-HT2 receptor binding was observed in both the patients who had been medicated with neuroleptics at time of death and those who had not, at least 2 months prior to death. Thus, abnormalities of 5-HT receptor subtypes seem to exist in the brains of patients with chronic schizophrenia. 5-HT related agents might be beneficial for the treatment of schizophrenia.

Key words

Serotonin Serotonin1A(5-HT1A) receptor Serotonin2(5-HT2) receptor Schizophrenia Postmortem brain 


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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • Takeshi Hashimoto
    • 1
  • Noboru Kitamura
    • 1
  • Yasuo Kajimoto
    • 2
  • Yutaka Shirai
    • 2
  • Osamu Shirakawa
    • 1
  • Tatsuo Mita
    • 3
  • Naoki Nishino
    • 1
  • Chikako Tanaka
    • 2
  1. 1.Department of Psychiatry and NeurologyKobe University School of MedicineKobeJapan
  2. 2.Department of PharmacologyKobe University School of MedicineKobeJapan
  3. 3.Department of PsychiatrySaiseikai Nakatsu HospitalOsakaJapan

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