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Psychopharmacology

, Volume 111, Issue 3, pp 295–300 | Cite as

Dose-dependent effects of intravenous alprazolam on neuroendocrine, biochemical, cardiovascular, and behavioral parameters in humans

  • Ossama T. Osman
  • John K. Hsiao
  • William Z. Potter
Original Investigations

Abstract

Neuroendocrine, biochemical, cardiovascular, and behavioral parameters were assessed in seven normal volunteers for 2 h after intravenous administration of alprazolam (APZ). Three doses of APZ (0.003, 0.007, and 0.02 mg/kg) were administered to each subject in a random order with at least 4 days between infusions. Plasma growth hormone and sedation increased in a dose dependent manner after APZ, and there was a dose dependent change in the shape of the cortisol response to APZ. No dose-response relationships were evident for plasma ACTH and norepinephrine. These differences in dose-response relationships may reflect the involvement of multiple systems in controlling neuroendocrine, biochemical, and subjective responses to APZ infusion. The optimal dose of APZ needed to produce a neuroendocrine or behavioral change appears to differ depending on the parameter of interest.

Key words

Alprazolam Neuroendocrine parameters Cardiovascular parameters Biochemical parameters Behavioral parameters 

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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • Ossama T. Osman
    • 1
  • John K. Hsiao
    • 1
  • William Z. Potter
    • 1
  1. 1.Section on Clinical Pharmacology, Clinical Neuroscience BranchNational Institute of Mental HealthBethesdaUSA

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