Abstract
Subjects received acute doses of orally administered alcohol (0–1.0 g/kg) and intranasal cocaine (4–96 mg/70 kg) alone and in combination in two experiments. Results generally were consistent across both experiments. Cocaine administered alone improved Digit Symbol Substitution Test (DSST) performance, increased subject ratings of stimulant-like effects, heart rate and blood pressure, and decreased skin temperature. Alcohol administered alone disrupted DSST performance, increased ratings of drunkenness, heart rate and skin temperature, and decreased blood pressure. Combining cocaine and alcohol attenuated the disruptions in DSST performance observed with alcohol alone, and either did not change or attenuated the improvements in performance observed with cocaine alone. Combining the drugs also attenuated effects observed with the drugs alone on skin temperature and, to a lesser extent, blood pressure. By contrast, drug combinations increased heart rate above levels observed when cocaine or alcohol were administered alone. Effects of the drug combinations on subject ratings were variable.
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References
Bickel WK, Bigelow GE, Preston KL, Liebson IA (1989) Opioid drug discrimination in humans: stability, specificity and relation to self-reported drug effect. J Pharmacol Exp Ther 251:1053–1062
Data from the Drug Abuse Warning Network (DAWN) (1988). National Institute on Drug Abuse; Annual Data 1987, NIDA Statistical Series, No. 7, DHHS Pub. No. (ADM) 88-1584, Government Printing Office, Washington DC
Fischman MW, Schuster CR (1980) Cocaine effects in sleep-deprived humans. Psychopharmacology 72:1–8
Fischman MW, Schuster CR, Resnekov L, Schick JFE, Krasnegor NA, Fennell W, Freedman DX (1976) Cardiovascular and subjective effects of intravenous cocaine administration in humans. Arch Gen Psychiatry 33:983–989
Foltin RW, Fischman MW (1989) Ethanol and cocaine interactions in humans: cardiovascular consequences. Pharmacol Biochem Behav 31:877–883
Fraser HF, Van Horn GD, Martin WR, Wolbach AB, Isbell H (1961) Methods for evaluating addiction liability. (A) “Attitude” of opiate addicts toward opiate-like drugs, (B) a short term addiction test. J Pharmacol Exp Ther 133, 371–387.
Grant BF, Harford TC (1990) Concurrent and simultaneous use of alcohol with cocaine: results of national survey. Drug Alcohol Depend 25:97–104
Higgins ST, Bickel WK, O'Leary DK, Yingling J (1987) Acute effects of ethanol and diazepam on the acquisition and performance of response sequences in humans. J Pharmacol Exp Ther 243:1–8
Higgins S, Capeless M, Hughes J, Bickel W, Belinson M (1988) Behavioral and cardiovascular effects of alcohol andd-amphetamine combinations in normal volunteers. In: Harris LS (ed) Problems of Drug Dependence, 1988, Proceedings of the 50th Annual Scientific Meeting, The Committee on Problems of Drug Dependence, Inc., NIDA Research Monograph Series # 90, US Government Printing Office (ADM) 89-1605, Washington, DC, pp 35–36
Higgins ST, Bickel WK, Hughes JR, Lynn M, Capeless MA, Fenwick JW (1990) Effects of intranasal cocaine on human learning, performance, and physiology. Psychopharmacology 102:451–458
Higgins ST, Rush CR, Hughes JR, Bickel WK, Lynn M, Capeless MA (1992) Effects of cocaine and alcohol, alone and in combination, on human learning and performance. J Exp Anal Behav 58:87–105
Holloway JA, Holloway FA (1979) Combined effects of ethanol and stimulants on behavior and physiology. Neurosci Biobehav Rev 3:137–148
Javaid JL, Fischman MW, Schuster CR, Dekirmenjian H, Davis JM (1978) Cocaine plasma concentration: relation to physiological and subjective effects in humans. Science 202:227–228
Jonsson J, Lewander T (1973) Effects of diethyldithiocarbamate and ethanol on the in vivo metabolism and pharmacokinetics of amphetamine in the rat. J Pharm Pharmacol 25:589–591
Katz JL, Terry P, Witkin JM (1992) Comparative behavioral pharmacology and toxicology of cocaine and its ethanol-derived metabolite, cocaine ethyl-ester (cocaethylene). Life Sci 50:1351–1361.
Kreek MJ (1987) Multiple drug abuse patterns and medical consequences. In: Meltzer HY (ed) Psychopharmacology: the third generation of progress Raven Press, New York, pp 1597–1604
Laties VG, Weiss B (1981) The amphetamine margin in sports. Fed Proc 40:2689–2692
McLeod DR, Griffiths RR, Bigelow GE, Yingling J (1982) An automated version of the digit symbol substitution test (DSST). Behav Res Methods Instr 14:463–466
Perez-Reyes M, White WR, McDonald SA, Hicks RE (1992) Interaction between ethanol and detroamphetamine: effects on psychomotor performance. Alcohol Clin Exp Res 16:75–81
Rech RH, Vomachka MK, Rickert DE (1978) Interactions between depressants (alcohol-type) and stimulants (amphetamine-type). Pharmacol Biochem Behav 8:143–151
Weiss B, Laties VG (1962) Enhancement of human performance by caffeine and the amphetamines. Pharmacol Rev 14:1–36
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Higgins, S.T., Rush, C.R., Bickel, W.K. et al. Acute behavioral and cardiac effects of cocaine and alcohol combinations in humans. Psychopharmacology 111, 285–294 (1993). https://doi.org/10.1007/BF02244943
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DOI: https://doi.org/10.1007/BF02244943