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Psychopharmacology

, Volume 112, Issue 2–3, pp 249–252 | Cite as

Effects of oxotremorine on inhibitory avoidance behaviour in two inbred strains of mice: interaction with 5-methoxy-NN-dimethyltriptamine

  • Flaminia Pavone
  • Sandro Fagioli
  • Claudio Castellano
Original Investigations

Abstract

The effects of the cholinergic muscarinic agonist, oxotremorine (0.005, 0.01, 0.02 and 0.04 mg/kg), the serotonergic agonist, 5-methoxy-NN-dimethyltriptamine (5-MeODMT) (0.5, 1 and 2 mg/kg), and their combination, were investigated in C57BL/6 and DBA/2 mice using a one-trial inhibitory avoidance task, drug treatment being given immediately after the acquisition trial. Post-trial administration of oxotremorine facilitated, while post-trial administration of 5-MeODMT inhibited memory retention of both strains in a dose-dependent fashion. The DBA/2 strain was more affected by oxotremorine than the C57BL/6 mice; no strain-dependent sensitivity to serotonergic agonist administration was observed. In both strains, the combination of oxotremorine plus 5-MeODMT inhibited the performance improvement shown by the administration of the cholinergic agonist alone. The facilitatory role of cholinergic stimulation on retention performance was confirmed and an inhibitory action of the serotonergic system on memory processes was suggested. Moreover, the present results support a functional interaction between cholinergic and serotonergic systems on memory consolidation.

Key words

Oxotremorine 5-MeODMT Memory retention Passive avoidance Cholinergic-serotonergic interaction Mouse 

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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • Flaminia Pavone
    • 1
  • Sandro Fagioli
    • 1
  • Claudio Castellano
    • 1
  1. 1.Istituto di Psicobiologia e Psicofarmacologia, CNRRomaItaly

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