Two elderly patients with Parkinson's disease were treated with nicotine gum and patch. Reliable changes in symptomatology were noted, using a single-subject, placebo-control reversal design. Improvement was associated with active nicotine dosing and involved diminished tremor and disorganized thinking in one patient and diminished bradykinesia and increased energy in the other.
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Fagerström, K.O., Pomerleau, O., Giordani, B. et al. Nicotine may relieve symptoms of Parkinson's disease. Psychopharmacology 116, 117–119 (1994). https://doi.org/10.1007/BF02244882