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Effect of switching carbamazepine to oxcarbazepine on the plasma levels of neuroleptics. A case report

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Carbamazepine was switched to its 10-keto analogue oxcarbazepine among six difficult-to-treat schizophrenic or organic psychotic patients using concomitantly haloperidol, chlorpromazine or clozapine. This change resulted within 2–4 weeks in the 50–200% increase in the plasma levels of these neuroleptics and the appearance of extrapyramidal symptoms. None of the patients showed any clinical deteriotation during the following 3–6 months. The results of this case report support the idea that in contrast with carbamazepine oxcarbazepine does not induce the hepatic microsomal enzyme systems regulating the inactivation of antipsychotic drugs.

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  • Grant SM, Faulds D (1992) Oxcarbazepine. A review of its pharmacological and therapeutic potential in epilepsy, trigeminal neuralgia and affective disorders. Drugs 43:873–888

    Google Scholar 

  • Keys PW, Stafford RW (1981) Digoxin: Therapeutic use and serum concentration monitoring. In: Taylor WJ, Finn AL (eds) Individualizing drug therapy: practical application of drug monitoring, 3. Gross, Townsend, Frank, Washington, pp 1–21

    Google Scholar 

  • Kidron R, Averbuch I, Klein E, Belmaker RH (1985) Carbamazepine induced reduction of blood levels of haloperidol in chronic schizophrenia. Biol Psychiatry 20:199–228

    Google Scholar 

  • Larkin JG, McKee PJW, Forrest G, Beastall GH, Park BK et al. (1991) Lack of enzyme induction with oxcarbazepine (600 mg daily) in healthy subjects. Br J Clin Pharmacol 31:65–71

    Google Scholar 

  • Minaly GW, Phillips JA, Louis WJ, Vajeta FJ (1977) Measurement of carbamazepine and its epoxide metabolite by high-performance liquid chromatography, and a comparison of assay techniques for the analysis of carbamazepine. Clin Chem 23:2283–2287

    Google Scholar 

  • Miller RL, DeVane CL (1986) Measurement of haloperidol and reduced haloperidol in human plasma using reversed-phase high-performance liquid chromatography. J Chromatogr 374:405–408

    Google Scholar 

  • Raitasuo V, Lehtovaara R, Huttunen MO (1993) Carbamazepine and plasma levels of clozapine. Am J Psychiatry 150:169

    Google Scholar 

  • Richter K (1988) Determination of clozapine in human serum by capillary gas chromatography. J Chromatogr 423:465–468

    Google Scholar 

  • Smith CS, Morgan SL, Green SV (1987) Solid-phase extraction and high-performance liquid chromatographic method for chlorpromazine and thirteen metabolites. J Chromatogr 423:207–216

    Google Scholar 

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Raitasuo, V., Lehtovaara, R. & Huttunen, M.O. Effect of switching carbamazepine to oxcarbazepine on the plasma levels of neuroleptics. A case report. Psychopharmacology 116, 115–116 (1994).

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