Abstract
ICV bicuculline, a selective GABAA antagonist, dose-dependently induced clonic-tonic convulsions in mice. Coadministration of ICV morphine (μ opioid agonist) significantly potentiated ICV bicuculline-induced convulsions, and this effect of morphine was completely blocked by pretreatment withβ-funaltrexamine (β-FNA), a μ antagonist. ICV glibenclamide, a selective ATP-sensitive potassium (KATP) channel blocker, at a dose which alone did not affect the convulsive threshold of bicuculline, was capable of blocking the exacerbation of ICV bicuculline-induced convulsions by morphine. The present data further suggest that KATP channels may play a tonic regulatory role in the potentiative effect of morphine on ICV bicuculline-induced convulsions.
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Abbreviations
- ICV:
-
intracerebroventricular injection
- KATP :
-
adenosine triphosphate-sensitive potassium
- GABA:
-
γ-aminobutyric acid
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Narita, M., Takahashi, Y., Suzuki, T. et al. An ATP-sensitive potassium channel blocker abolishes the potentiating effect of morphine on the bicuculline-induced convulsion in mice. Psychopharmacology 110, 500–502 (1993). https://doi.org/10.1007/BF02244659
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DOI: https://doi.org/10.1007/BF02244659