Psychopharmacology

, Volume 100, Issue 3, pp 339–344 | Cite as

Effects ofm-chlorophenylpiperazine in normal subjects: a dose-response study

  • R. S. Kahn
  • S. Wetzler
  • G. M. Asnis
  • M. A. Kling
  • R. F. Suckow
  • H. M. van Praag
Original Investigations

Abstract

m-Chlorophenylpiperazine (MCPP), a direct 5HT receptor agonist, was administered orally to 20 normal subjects in two doses (0.25 and 0.5 mg/kg) in a placebo-controlled design. Behavioral responses; ACTH, cortisol, prolactin and MCPP blood level; temperature and pulse rate were measured over a 210-min period after administration of tablets. Non-linear dose-response relationships between MCPP and ACTH, cortisol and prolactin response were found. On the higher dose, a significant increase in the number of physical symptoms was also noted and three subjects (15%) had a panic attack, while one subject (5%) had a panic attack on the lower dose. No effects on other behavioral variables, pulse rate and temperature were found using either dose. These findings attest to the usefulness of MCPP as a challenge agent to assess 5HT receptor hypersensitivity when given at a low oral dose (i.e. around 0.25 mg/kg), and to assess 5HT receptor hyposensitivity when given at higher oral doses (i.e. around 0.5 mg/kg).

Key words

m-Chlorophenylpiperazine Serotonin Dose-response Normal subjects 

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • R. S. Kahn
    • 1
  • S. Wetzler
    • 1
  • G. M. Asnis
    • 1
  • M. A. Kling
    • 2
  • R. F. Suckow
    • 3
  • H. M. van Praag
    • 1
  1. 1.Department of Psychiatry, Albert Einstein College of MedicineMontefiore Medical CenterNew YorkUSA
  2. 2.Clinical Neuroendocrinology Branch, NIMH/DIRPBethesdaUSA
  3. 3.Analytical Psychopharmacology LaboratoryNew York State Psychiatric InstituteNew YorkUSA

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