Skip to main content

One-trial tolerance to the anxiolytic effects of chlordiazepoxide in the plus-maze

Abstract

Chlordiazepoxide (CDP 7.5 mg/kg) had a significant anxiolytic effect in rats tested on the plus-maze for the first time. On a second trial the control scores did not change, but those of the CDP group did and they no longer differed from controls. Rats previously tested undrugged or after flumazenil (4 mg/kg) also failed to show an anxiolytic response to CDP. Thus this phenomenon of one-trial tolerance depended on prior experience with the plus-maze. It also depended on CDP acting at the benzodiazepine receptors on trial 2, since the joint administration of CDP and flumazenil on trial 2 reversed the phenomenon.

This is a preview of subscription content, access via your institution.

References

  • File SE (1985) Tolerance to the behavioral actions of benzodiazepines. Neurosci Biobehav Rev 9:113–121

    Article  PubMed  Google Scholar 

  • File SE, Baldwin HA (1989) Changes in anxiety in rats tolerant to, and withdrawn from, benzodiazepines: behavioural and biochemical studies. In: Tyrer P (ed) Psychopharmacology of anxiety. Oxford University Press, Oxford, pp 28–51

    Google Scholar 

  • File SE, Baldwin HA, Aranko K (1987) Anxiogenic effects from benzodiazepine withdrawal are linked to the development of tolerance. Brain Res Bull 19:607–610

    Article  PubMed  Google Scholar 

  • Lister RG (1987) The use of a plus-maze to measure anxiety in the mouse. Psychopharmacology 92:180–185

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

File, S.E. One-trial tolerance to the anxiolytic effects of chlordiazepoxide in the plus-maze. Psychopharmacology 100, 281–282 (1990). https://doi.org/10.1007/BF02244419

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02244419

Key words

  • Learned tolerance
  • Anxiety
  • Benzodiazepines