Response to selection for ethanol-induced locomotor activation: genetic analyses and selection response characterization
- 28 Downloads
Selectively bred FAST mice are highly susceptible, while SLOW mice are less susceptible, to the locomotor stimulant effects of ethanol. Heritability estimates indicate that approximately 15% of the variance in the FAST lines is of additive genetic origin, while low susceptibility is ostensibly nonheritable. Inbreeding has increased at the rate of 2% per generation, but fertility has been unaffected. Measurement reliability for sensitivity to this ethanol effect was high when measured in both circular (r=0.6) and square (r=0.7) open-fields. In addition, our results indicate that we have selected for differences in sensitivity to ethanol rather than for differences in habituation to the test environment. The difference in response to ethanol between FAST and SLOW mice extended to tests varying in duration, and to a range of ethanol doses. We conclude that the divergence between FAST and SLOW mice generalizes to related test parameters, and speculate that the genetic architecture underlying the locomotor stimulant response may be simpler than previously proposed.
Key wordsSelective breeding FAST and SLOW mice Ethanol-stimulated activity Heritability
Unable to display preview. Download preview PDF.
- Bijerot N (1980) Addiction to pleasure: a biological and social-psychological theory of addiction. In: Lettieri DJ, Sayers M, Pearson HW (eds) Theories on drug abuse: selected contemporary perspectives. National Institute on Drug Abuse, Rockville, pp 246–255Google Scholar
- Crabbe JC, Kosobud A, Feller DJ, Phillips TJ (1989) Use of selectively bred mouse lines to study genetically correlated traits related to alcohol. In: Kuriyama K, Takada A, Ishii H (eds) Biomedical and social aspects of alcohol and alcoholism. Excerpta Medica, Elsevier, Amsterdam, pp 427–430Google Scholar
- Crabbe JC, Phillips TJ, Kosobud A, Belknap JK (1990) Estimation of genetic correlation: interpretation of experiments using selectively bred and inbred animals. Alcoholism: Clin Exp Res 14:141–151Google Scholar
- Eriksson K, Rusi M (1981) Finnish selection studies on alcohol-related behaviors: general outline. In: McClearn GE, Deitrich RA, Erwin VG (eds) Development of animal models as pharmacogenetic tools. US Government Printing Office, Washington, pp 87–117Google Scholar
- Falconer DS (1983) Introduction to quantitative genetics, 2nd edn. Longman, New YorkGoogle Scholar
- Gora-Maslak G, McClearn GE, Crabbe JC, Phillips TJ, Belknap JK, Plomin R (1991) Use of recombinant inbred strains to identify quantitative trait loci in psychopharmacology. Psychopharmacology (in press)Google Scholar
- Keppel G (1973) Design and analysis: a researcher's handbook Prentice-Hall, Englewood Cliffs, New JerseyGoogle Scholar
- McClearn GE, Kakihana R (1981) Selective breeding for ethanol sensitivity: Short-Sleep and Long-Sleep mice. In: McClearn GE, Deitrich RA, Erwin VG (eds) Development of animal models as pharmacogenetic tools. US Government Printing Office, Washington, pp 147–159Google Scholar
- Phillips TJ, Limm M, Crabbe JC (1989b) Correlated behavioral responses as potential predictors of sensitivity to ethanol's rewarding effects and addiction liability. In: Kiianmaa K, Tabakoff B, Saito T (eds) Genetic aspects of alcoholism. The Finnish Foundation for Alcohol Studies, Helsinki, pp 197–206Google Scholar