Abstract
The amount of wakefulness and slow wave sleep (SWS) during the 12-h light period slightly but significantly decreased and increased, respectively, in freely behaving rats after continued 1-week intake of Panax ginseng extract through drinking water (15 mg/day). Paradoxical sleep was little affected. No sleep parameters were modulated by the treatment during the dark period. The diurnal SWS enhancement disappeared and recovered to the baseline level after 2 weeks of continued treatment. It is speculated that the well known health-improving effect of the ginseng may be, at least in part, related to an enhancement of sleep.
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References
Brekhman II, Dardymov IV (1969) New substances of plant origin which increase nospecific resistance. Ann Rev Pharmacol 9:419–430
Chang WA, Kim C (1974) Influence of Panax ginseng upon gastric ulceration produced by restraint. J Cath Med Coll 27:249–255
Honda K, Inoué S (1978) Establishment of a bioassay method for the sleep-promoting substance. Rep Inst Med Dent Eng 12:81–85
Honda K, Inoué S (1981) Effects of sleep-promoting substance on sleep-waking patterns of male rats. Rep Inst Med Dent Eng 15:115–123
Honda K, Inoué S (1988) Sleep-promoting effects of a bracket fungus, Fomes japonicus. In: Koella WP, Obál F, Schulz H, Visser P (eds) Sleep '86. G. Fischer, Stuttgart, pp 338–339
Honda K, Komoda Y, Inoué S (1988) Sleep-promoting effects ofGanoderma extracts in rats: comparison between long-term and acute administrations. Rep Inst Med Dent Eng 22:77–82
Hou JP (1977) The chemical constituents of ginseng plants. Comp Med East West 5:123–145
Hu SY (1977) A contribution to our knowledge of ginseng. Am J Chin Med 5:1–23
Kim AE, Kim CC (1984) Effect of ginseng on the serum fatty acid composition in the rats. J Cath Med Coll 37:55–61
Lee BK, Kim CC (1984) Change of the serum composition in the rats receiving ginseng. J Cath Med Coll 37:47–53
Lee SP, Honda K, Rhee YH, Inoué S (1990) Chronic intake ofPanax ginseng extract stabilizes sleep and wakefulness in food-deprived rats. Neurosci Lett 111:217–221
Lee SP, Rhee YH, Honda K, Inoué S (1989) Effect of the ginseng extract on sleep in unrestrained rats. Jpn J Psychiatry Neurol 43:776
Li CP, Li RC (1973) An introductory note to ginseng. Am J Chin Med 1:249–261
Lim SY, Kim CC (1982) Influence upon male rats' sexual behavior of ginseng administered before and after mature state. J Cath Med Coll 35:9–14
Nabata H, Saito H, Takagi, K (1973) Pharmacological studies of neutral saponins (GNS) of Panax ginseng root. Jpn J Pharmacol 23:29–41
Saito H, Morita M, Takagi, K (1973) Pharmacological studies of Panax ginseng leaves. Jpn J Pharmacol 23:43–56
Saito H, Tsuchiya M, Naka S, Takagi, K (1977) Effects of Panax ginseng root on conditioned response in rats. Jpn J Pharmacol 27:509–516
Takagi, K, Saito H, Nabata H (1972a) Pharmacological studies of Panax ginseng root: estimation of pharmacological actions of Panax ginseng root. Jpn J Pharmacol 22:245–259
Takagi, K, Saito H, Tsuchiya M (1972b) Pharmacological studies of Panax ginseng root: pharmacological properties of a crude saponin fraction. Jpn J Pharmacol 22:339–346
Yamamura Y, Kumagai A, Oura H, Okuda T, Morisawa S, Yamamoto M (eds) (1989) Medicinal ginseng: progress in its basic and clinical studies. Kyoritsu Shuppan, Tokyo
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Rhee, Y.H., Lee, S.P., Honda, K. et al. Panax ginseng extract modulates sleep in unrestrained rats. Psychopharmacology 101, 486–488 (1990). https://doi.org/10.1007/BF02244226
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DOI: https://doi.org/10.1007/BF02244226