, Volume 101, Issue 4, pp 465–471 | Cite as

Role of D-1 and D-2 receptor stimulation in sensitization to amphetamine-induced circling behavior and in expression and extinction of the Pavlovian conditioned response

  • Kelly L. Drew
  • Stanley D. Glick
Original Investigations


Circling behavior was measured in female rats treated with amphetamine (1.25 mg/kgd-amphetamine sulfate, IP) on 3 consecutive days. On days 4 and 5 saline was substituted for amphetamine. While the amphetamine-induced response was attenuated by both a D-1 (SCH 23390) and a D-2 (metoclopramide) antagonist, sensitization to amphetamine was attenuated by the D-1 antagonist only. In addition, expression of a placebo-like response observed on day 4 (characterized previously as a Pavlovian conditioned response) was attenuated by both the D-1 and D-2 antagonists without disrupting extinction of the response.

Key words

Amphetamine sensitization Pavlovian conditioning Amphetamine-induced circling behavior SCH 23390 Metoclopramide 


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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • Kelly L. Drew
    • 1
  • Stanley D. Glick
    • 1
  1. 1.Department of Pharmacology and ToxicologyAlbany Medical CollegeAlbanyUSA

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