Abstract
The conditioned place preference technique was used to assess the affective properties of the direct dopamine D1 agonist, SKF38393, and the direct D2 agonist, LY171555 (quinpirole). A three compartment apparatus was used: the animals' pre-experimental preference for the two choice compartments was equal and, within each experimental group, half the rats received drug pairings in each choice compartment. Intraperitoneal injections of SKF38393 produced conditioned place aversions at all doses tested (1.0–4.0 mg/kg); LY171555 produced weak conditioned place preferences at 1.0 and 2.0 mg/kg, but no reliable effect at 4.0 mg/kg. Bilateral intra-accumbens microinjections of SKF38393 produced strong preferences at all doses tested (0.5–2.0 µg/side); LY171555 produced strong preferences at two doses (0.5 and 1.0 µg/side) and no effect at a third dose (2.0 µg/side). These results suggest that activation of either D1 or D2 receptors in the nucleus accumbens can produce reward, and that D1 receptors (and possibly also D2 receptors) located elsewhere in the brain or in the periphery may mediate aversive effects.
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References
Asin KE, Montana WE (1989) Studies on D1 and D2 dopamine receptor involvement in conditioned taste aversions. Pharmacol Biochem Behav 32:1033–1041
Bechara A, van der Kooy D (1985) Opposite motivational effects in brain and periphery. Nature 314:533–534
Blackburn JR, Phillips AG, Fibiger HC (1987) Dopamine and preparatory behavior: I. Effects of pimozide. Behav Neurosci 101:352–360
Blackburn JR, Phillips AO, Jakubovic A, Fibiger HC (1989) Dopamine and preparatory behavior: II. A neurochemical analysis. Behav Neurosci 103:15–23
Carr GD, White NM (1983) Conditioned place preference from intra-accumbens but not intracaudate amphetamine injections. Life Sci 33:2551–2557
Carr GD, White NM (1986) Anatomical dissociation of amphetamine's rewarding and aversive effects: an intracranial microinjection study. Psychopharmacology 89:340–346
Carr GD, Fibiger HC, Phillips AG (1989) Conditioned place preference as a measure of drug reward. In: Leibman JM, Cooper SJ (eds), Oxford reviews in physhopharmacology. Oxford University Press, Oxford
Dreher JK, Jackson DM (1989) Role of D1 and D2 dopamine receptors in mediating locomotor activity elicited from the nucleus accumbens of rats. Brain Res 487:267–277
Ettenberg A, Sgro S, White NM (1982) Algebraic summation of the affective properties of a rewarding and an aversive stimulus in the rat. Physiol Behav 28:873–877
Gower AJ, Marriott AS (1982) Pharmacological evidence for the subclassification of central dopamine receptors in the rat. Br J Pharmacol 77:185–194
Hadjiconstantinou M, Neff NH (1987) Is dopamine a transmitter in the periphery?. Neuropharmacology 26:809–814
Hall G, Pearce JM (1979) Latent inhibition of a CS during CS-US pairings. J Exp Psychol: Anim Behav Proc 5:31–42
Heimer L, Wilson RD (1975) The subcortical projections of the allocortex: similarities in the neural associations of the hippocampus, the piriform cortex and the neocortex. In: Santini M (ed) Golgi centennial symposium. Proceedings Raven Press, New York, pp 177–193
Hoffman DG, Beninger RJ (1988) Selective D1 and D2 dopamine agonists produce opposing effects in place conditioning but not in conditioned taste aversion learning. Pharmacol Biochem Behav 31:1–8
Hoffman DC, Beninger RJ (1989) The effects of selective dopamine D1 or D2 receptor antagonists on the establishment of agonist-induced place conditioning in rats. Pharmacol Biochem Behav 33:273–279
Hori Y, Fujita A, Koike K, Hirose K (1983) Comparison of inhibitory effects of substituted benzamides and classical neuroleptics on operant behavior in rats and squirrel monkeys. Eur J Pharmacol 88:37–46
Kebabian JW, Calne DB (1979) Multiple receptors for dopamine. Nature 277:93–96
Kelly E, Nahorski SR (1987) Dopamine D2 receptors inhibit D1 stimulated cyclic AMP accumulation in striatum but not limbic forebrain. Naunyn Schmiedeberg's Arch Pharmacol 335:508–512
Kurumiya S, Nakajima S (1988) Dopamine D1 receptors in the nucleus accumbens: involvement in the reinforcing effect of tegmental stimulation. Brain Res 448:1–6
Mogenson GJ (1987) Limbic — motor integration. In: Epstein AM, Morrison AR (eds) Proggress in psychobiology and phychological psychology, 13th ed. Academic Press, Orlando, FL, pp 117–170
Nakajima S, McKenzie GM (1986) Reduction of the rewarding effect of brain stimulation by a blockade of dopamine D1 receptor with SCH23390. Pharmacol Biochem Behav 24:919–923
Papp M (1988) Different effects of short- and long-term treatment with imipramine on the apomorphine- and food-induced place preference conditioning in rats. Pharmacol Biochem Behav 30:889–893
Paxinos G, Watson C (1982) The rat brain in stereotaxic coordinates. Academic Press, Sydney
Phillips AG, Spyraki C, Fibiger HC (1982) Conditioned place preference with amphetamine and opiates as reward stimuli: attenuation by haloperidol. In: Hoebel BG, Novin D (eds) The neural basis of feeding and reward. Haer Institute, Brunswik ME, pp 455–464
Reicher MA, Holman EW (1977) Location preference and flavor aversion reinforced by amphetamine in rats. Anim Learn Behav 5:343–346
Seeman P (1981) Brain dopamine receptors. Pharmacol Rev 32:229–313
Spyraki C, Fibiger HC, Phillips AG (1982) Dopaminergic substrates of amphetamine-induced place preference conditioning. Brain Res 253:185–193
Spyraki C, Nomikos GG, Galanopoulou P, Dafotis Z (1988) Drug-induced conditioned place preference in rats with 5,7-dihydroxytryptamine lesions of the nucelus accumbens. Behav Brain Res 29:127–134
Starr MS, Starr BS (1989) Behavioural synergism between the dopamine agonists SKF 38393 and LY 171555 in dopamine-depleted mice: antagonism by sulpiride reveals only stimulant postsynaptic D-2 receptors. Pharmacol Biochem Behav 33:41–44
Stolerman IP, D'Mello GD (1978) Amphetamine-induced taste aversion demonstrated with operant behaviour. Pharmacol Biochem Behav 8:107–111
Stoof JO, Kebabian JW (1984) Two dopamine receptors: biochemistry, physiology and pharmacology. Life Sci 35:2281–2296
Stoof JC, Verheijden PFHM (1986) D2 receptor stimulation inhibits cyclic AMP formation brought about by D1 receptor stimulation in rat neostriatum but not nucleus accumbens. Eur J Pharmacol 129:205–206
Tsuruta K, Frey EA, Grewe CW, Cote TE, Eskay RL, Kebabian JW (1981) Evidence that LY-141865 specifically stimulates the D-2 dopamine receptor. Nature 292:463–465
van der Kooy D, Swerdlow NR, Koob GF (1983) Paradoxical reinforcing properties of apomorphine: effects of nucleus accumbens and area postrema lesions. Brain Res 259:111–118
Walters JR, Bergstrom DA, Carlson JH, Chase TN, Braun AR (1987) D1 dopamine receptor activation required for postsynaptic expression of D2 agonist effects. Science 236:719–722
White NM, Messier C, Carr GD (1987) Operationalizing and measuring the organizing influence of drugs on behavior. In: Bozarth MA (ed) Methods of measuring the reinforcing properties of abused drugs. Springer, Berlin Heidelberg New York, pp 591–618
Wise RA (1982) Neuroleptics and operant behavior: the anhedonia hypothesis. Behav Brain Sci 5:39–87
Woolverton WL, Goldberg LI, Ginos JZ (1984) Intravenous self-administration of dopamine receptor agonists in rhesus monkeys. J Pharmacol Exp Ther 230:268–283
Young PT, Christensen KR (1962) Algebraic summation of hedonic processes. J Comp Physiol Psychol 55:332–336
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White, N.M., Packard, M.G. & Hiroi, N. Place conditioning with dopamine D1 and D2 agonists injected peripherally or into nucleus accumbens. Psychopharmacology 103, 271–276 (1991). https://doi.org/10.1007/BF02244216
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DOI: https://doi.org/10.1007/BF02244216