Response to marijuana as a function of potency and breathhold duration


The present study examined the effects of systematic manipulation of breathhold duration (0 and 20 s) on the physiological and subjective response to active (M; 2.3% delta-9-THC) and placebo (P; 0.0% delta-9-THC) marijuana in a group of ten regular marijuana smokers. During the eight-session experiment, subjects were exposed twice to each of four experimental conditions (P0, P20, M0, M20), scheduled according to a randomized block design. A controlled smoking procedure was used in which the number of puffs and puff volume were held constant. Expired-air carbon monoxide (CO) levels were used to monitor smoke intake. Breathhold duration affected CO absorption; significantly more CO was absorbed from both P and M smoke after 20 s of breathholding (mean CO boost=6.9 ppm) than after no breathholding (mean=4.4 ppm). Heart rate was minimally affected by the breathhold manipulation. Effects of marijuana on mood were not consistently affected by breathhold duration. The results confirm previous findings that prolonged breathholding does not substantially enhance the effects of inhaled marijuana smoke.

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  1. Chait LD, Fischman MW, Schuster CR (1985) “Hangover” effects the morning after marijuana smoking. Drug Alcohol Depend 15:229–238

    Google Scholar 

  2. Dixon WJ (ed) (1983) BMDP statistical software. University of California Press, Berkeley

    Google Scholar 

  3. Perez-Reyes M, DiGuiseppi S, Davis KH, Schindler VH, Cook CE (1982) Comparison of effects of marijuana cigarettes of three different potencies. Clin Pharmacol Ther 31:617–624

    Google Scholar 

  4. Perez-Reyes M, Owens SM, DiGuiseppi S (1981) The clinical pharmacology and dynamics of marijuana cigarette smoking. J Clin Pharmacol [Suppl 8–9] 21:201S-207S

    Google Scholar 

  5. Wu TC, Tashkin DP, Djahed B, Rose JE (1988) Pulmonary hazards of smoking marijuana as compared with tobacco. N Engl J Med 318:347–351

    Google Scholar 

  6. Zacny JP, Chait LD (1989) Breathhold duration and response to marijuana smoke. Pharmacol Biochem Behav 33:481–484

    Google Scholar 

  7. Zacny JP, Stitzer ML, Brown FJ, Yingling JE, Griffiths RR (1987) Human cigarette smoking: effects of puff and inhalation parameters on smoke exposure. J Pharmacol Exp Ther 240:554–564

    Google Scholar 

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Correspondence to L. D. Chait.

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Zacny, J.P., Chait, L.D. Response to marijuana as a function of potency and breathhold duration. Psychopharmacology 103, 223–226 (1991).

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Key words

  • Marijuana
  • Smoking
  • Smoking topography
  • Human
  • Carbon monoxide
  • Subjective effects