, Volume 103, Issue 2, pp 143–149 | Cite as

Serotonin, memory, and the aging brain

  • William J. McEntee
  • Thomas H. Crook


Serotonin is widely distributed throughout the central nervous system and is implicated in a variety of neural functions such as pain, feeding, sleep, sexual behavior, cardiac regulation and cognition. This paper is concerned with the last of these. Abnormalities of the serotonergic nervous system are well documented in pathologic studies of Alzheimer's disease and there is evidence suggesting that changes in this system occur in association with non-disease aging. Data on the role of serotonin in learning and memory and on the effects of aging on brain serotonin function are reviewed and discussed in relation to pharmacologic treatment strategies for the memory impairments associated with advancing age.

Key words

Serotonin Monoamines Memory Aging 


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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • William J. McEntee
    • 1
  • Thomas H. Crook
    • 2
  1. 1.Memory Assessment Clinics Inc.SarasotaUSA
  2. 2.Memory Assessment Clinics Inc.BethesdaUSA

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