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Stereospecific blockade of N-methyl-d-aspartate transmission by MK 801 prevents priming of SKF 38393-induced turning

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Abstract

In rats unilaterally lesioned with 6-hydroxydopamine, the D-1 agonist SKF 38393 (3 mg/kg SC) induced contralateral turning only after priming with a dopaminergic agonist such as apomorphine. Administration of the N-methyl-d-aspartate receptor antagonist (+) MK 801 (0.1 mg/kg IP) 15 min before apomorphine (0.1 mg/kg SC) prevented the ability of apomorphine to act as a primer while potentiating its acute contralateral turning effects. The inactive isomer (−) MK 801 was without effect. The results indicate that the N-methyl-d-aspartate receptor exerts a permissive role on priming.

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Authors and Affiliations

  1. Institute of Experimental Pharmacology and Toxicology, University of Cagliari, Viale A. Diaz 182, I-09100, Cagliari, Italy

    M. Morelli & G. Di Chiara

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  1. M. Morelli
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  2. G. Di Chiara
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Morelli, M., Di Chiara, G. Stereospecific blockade of N-methyl-d-aspartate transmission by MK 801 prevents priming of SKF 38393-induced turning. Psychopharmacology 101, 287–288 (1990). https://doi.org/10.1007/BF02244143

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  • DOI: https://doi.org/10.1007/BF02244143

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