Abstract
In a placebo-controlled trial, pupillary constriction was measured in healthy non-addicted subjects and in opiate addicts by using static computer-assisted pupillometry. In contrast to earlier reports, a clear-cut pupillary constriction was observed in healthy persons after a single intravenous injection of 0.4 mg naloxone. No significant changes of pupillary size were recorded in the same subjects after the administration of a placebo. In methadone-maintained subjects, the IV administration of 0.4 mg naloxone caused a significant pupillary dilatation. From these data it can be concluded that naloxone seems to have a central pharmacological action not only in opiate addicts, but also in healthy persons. This is demonstrable by studying the miotic response.
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Loimer, N., Schmid, R., Grünberger, J. et al. Naloxone induces miosis in normal subjects. Psychopharmacology 101, 282–283 (1990). https://doi.org/10.1007/BF02244141
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DOI: https://doi.org/10.1007/BF02244141