Abstract
Low doses of 8-OH-DPAT (62.5–250 µg/kg) were reinforcing in the place preference conditioning procedure, while a higher dose (1 mg/kg) supported a conditioned place aversion. The 5-HT synthesis inhibitor PCPA, and the DA antagonists pimozide and sulpiride, had no effect when administered alone, but abolished the 8-OH-DPAT-induced place preference. However, neither PCPA nor pimozide altered the 8-OH-DPAT-induced place aversion. The results are consistent with other evidence showing that 8-OH-DPAT acts through different mechanisms at low and high doses, and support the hypothesis that low doses of 8-OH-DPAT act through 5-HT neurons to disinhibit dopaminergic activity.
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Papp, M., Willner, P. 8-OH-DPAT-induced place preference and place aversion: effects of PCPA and dopamine antagonists. Psychopharmacology 103, 99–102 (1991). https://doi.org/10.1007/BF02244082
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DOI: https://doi.org/10.1007/BF02244082