Abstract
The possible involvement of catecholamines (CA) in the mediation of acetaldehyde's conditioned taste aversion (CTA) was examined by testing the effects of alpha-methyl-para-tyrosine (AMPT, a tyrosine hydroxylase inhibitor) on the CTAs produced by acetaldehyde. AMPT blocked the acquisition of the CTA normally produced by a low dose of acetaldehyde (0.2 g/kg), but had no significant effect on CTA produced by a high dose of acetaldehyde (0.3 g/kg). In a second study, acetaldehyde's role in the CTA produced by ethanol was investigated using the pre-exposure conditioned taste aversion paradigm. Pre-exposure to acetaldehyde (both doses) blocked the ethanol CTAs but when pre-exposure with acetaldehyde was coupled with AMPT, only the larger dose of acetaldehyde blocked the ethanol aversion. These results suggest that while the CTA to the low dose of acetaldehyde may be primarily central and catecholamine-mediated, the mechanism underlying the high dose CTA is probably peripheral and emetic in nature. These findings support the conclusion that acetaldehyde may be mediating many of the actions of ethanol.
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References
Ahlenius S, Carlsson A, Engel J, Svensson H, Sodersten P (1973) Antagonism by alphamethyltyrosine of the ethanol-induced stimulation and euphoria in man. Clin Pharmacol Ther 14:586–591
Amit Z, Smith BR (1985) A multi-dimensional examination of the positive reinforcing properties of acetaldehyde. Alcohol 2:367–370
Aragon CMG, Abitbol M, Amit Z (1986) Acetaldehyde may mediate reinforcement and aversion produced by ethanol: an examination using a conditioned taste-aversion paradigm. Neuropharmacology 25:79–83
Brown ZW, Amit Z, Smith BR, Rockman GE (1978) Differential effects on conditioned taste aversion learning with peripherally and centrally administered acetaldehyde. Neuropharmacology 17:931–935
Brown ZW, Amit Z, Rockman GE (1979) Intraventricular self-administration of acetaldehyde but not ethanol in naive laboratory rats. Psychopharmacology 64:271–276
Davis WM, Smith SG (1972) Alpha-methyl-tyrosine to prevent self-administration of morphine and amphetamine. Curr Ther Res 14:814–819
Goudie AJ, Thornton EW, Wheatley J (1975) Attenuation by alpha-methyltyrosine of amphetamine induced conditioned taste aversions in rats. Psychopharmacologia 45:119–123
Hald J, Jacobsen E (1948) A drug sensitizing the organism to ethyl alcohol. Lancet II:1001–1002
Hunt T, Amit Z (1987) Conditioned taste aversion induced by self-administered drugs: paradox revisited. Neurosci Biobehav Rev 11:107–130
Lorden JF, Callahan M, Dawson R (1980) Depletion of central catecholamines alters amphetamine and fenfluramine induced taste aversion in the rat. J Comp Physiol Psychol 94:99–114
Myers WD, Ng KT, Singer G (1982) Intravenous self-administration of acetaldehyde in the rat as a function of schedule, food deprivation and photoperiod. Pharmacol Biochem Behav 17:807–812
Phillips AG (1984) Brain reward circuitry: a case for separate systems. Brain Res Bull 12:195–201
Roberts DCS, Fibiger HC (1975) Attenuation of amphetamine-induced conditioned taste aversion following intraventricular 6-hydroxydopamine. Neurosci Lett 1:343–347
Schlesinger K, Kakihana R, Bennett EH (1966) Effects of tetraethylthiuramidisulfide (Antabuse) on the metabolism and consumption of ethanol in mice. Psychosom Med 28:514–520
Sellers EM, Naranjo CA, Peachey JE (1981) Drugs to decrease alcohol consumption. N Engl J Med 805:1255–1262
Sklar LS, Amit Z (1977) Manipulations of catecholamine systems block the conditioned taste aversion induced by self-administered drugs. Neuropharmacology 16:649–655
Switzman L, Fishman B, Amit Z (1981) Pre-exposure effects of morphine, diazepam and delta-9 THC on the formation of conditioned taste aversion. Psychopharmacology 74:149–157
Takayama S, Uyeno ET (1985) Intravenous self-administration of ethanol and acetaldehyde by rats. Jpn J Psychopharmacol 5:329–334
Wise RA (1980) Action of drugs of abuse on brain reward systems. Pharmacol Biochem Behav 13:213–223
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Aragon, C.M.G., Abitbol, M. & Amit, Z. Ethanol-induced CTA mediated by acetaldehyde through central catecholamine activity. Psychopharmacology 103, 74–77 (1991). https://doi.org/10.1007/BF02244077
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DOI: https://doi.org/10.1007/BF02244077