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Psychopharmacology

, Volume 103, Issue 1, pp 28–32 | Cite as

Awakening properties of modafinil: effect on nocturnal activity in monkeys(Macaca mulatta) after acute and repeated administration

  • Jean-François Hermant
  • Francis A. Rambert
  • Jacques Duteil
Original Investigations

Abstract

Single oral administration of modafinil (16–64 mg/kg) in monkeys induced an increase in nocturnal activity and in behavioural arousal without stereotyped behaviour. Modafinil-induced increase in nocturnal activity was prevented by the centrally acting α1 adrenoceptor antagonist prazosin. After repeated oral administration of modafinil, b.i.d. for 5 days, nocturnal activity was still increased, but was lower than after a single administration; the gradual decrease appeared on the second night. No rebound of sleep and no residual effect on night 5 (when modafinil was administered for 4 days and placebo on day 5) were seen after the withdrawal of the drug. Therefore, modafinil appeared to produce strong behavioural stimulation and awakening in a non-human primate species, after single, as well as after repeated administration, without other obvious side-effects (no sign of anxiety, no behavioural trouble). These awakening properties involved a modulation (stimulation) of a central α1 adrenergic system.

Key words

Modafinil Prazosin Awakening α1-Adrenoceptor Nocturnal activity Rhesus monkey 

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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • Jean-François Hermant
    • 1
  • Francis A. Rambert
    • 1
  • Jacques Duteil
    • 1
  1. 1.Centre de Recherches du Laboratoire L. LafonMaisons-Alfort CedexFrance

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