, Volume 101, Issue 3, pp 429–430 | Cite as

The 5HT3 antagonist GR38032F is highly toxic in DBA/2 mice

  • C. A. Hendrie
Letter To The Editors


5HT3 Antagonist Antagonist GR38032F 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. Costall B, Hendrie CA, Kelly ME, Naylor RJ (1986) Actions of sulpiride and tiapride in a simple model of anxiety in mice. Neuropharmacology 26:195–200CrossRefGoogle Scholar
  2. Costall B, Domeney AM, Hendrie CA, Kelly ME, Naylor RJ (1987a) The anxiolytic activity of GR38032F in the mouse and marmoset. Br J Pharmacol 90:275PGoogle Scholar
  3. Costall B, Domeney AM, Kelly ME, Naylor RJ, Tyers MB (1987b) Antipsychotic potential of GR38032F, a selective antagonist of 5-HT3 receptors in the central nervous system. Br J Pharmacol 90:89PGoogle Scholar
  4. Costall B, Domeney AM, Naylor RJ, Tattersall FD, Tyers MB (1987c) GR38032F: a potent and novel inhibitor of cisplatin-induced emesis in the ferret. Br J Pharmacol 90:90PGoogle Scholar
  5. Costall B, Gunning SJ, Naylor RJ, Tyers MB (1987d) The effect of GR38032F, a novel 5-HT3 receptor antagonist on gastric emptying in the guinea pig. Br J Pharmacol 91:263–264PubMedGoogle Scholar
  6. Costall B, Naylor RJ, Tyers MB (1988) Recent advances in the neuropharmacology of 5-HT3 agonists and antagonists. Rev Neurol Sci 2:41–65Google Scholar
  7. Costall B, Domeney AM, Gerrard PA, Jones DNC, Naylor RJ, Tyers MB (1989) Effects of GR38032F on performance of common marmosets (Callithrix Jacchus) in an object discrimination task. Br J Pharmacol 98:637PGoogle Scholar
  8. Green AR (1984) 5-HT mediated behaviour — animal studies. Neuropharmacology 23:1521–1528CrossRefPubMedGoogle Scholar
  9. Jacobs BL (1976) An animal behaviour model for studying central serotonergic synapses. Life Sci 19:777–786CrossRefPubMedGoogle Scholar
  10. Jones BJ, Oakely NR, Tyers MB (1987) The anxiolytic activity of GR38032F, a 5-HT3 receptor antagonist, in the rat and cynomologous monkey. Br J Pharmacol 90:88PGoogle Scholar
  11. Tricklebank MD (1984) Behavioural effects of 8-hydroxy-2-(di-n-propylamine) tetralin, a putative 5HT1a receptor agonist. Br J Pharmacol 82:204PGoogle Scholar

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • C. A. Hendrie
    • 1
  1. 1.Department of PsychologyUniversity of BradfordBradfordUK

Personalised recommendations