In order to assess the presence of anxiolytic properties in cannabidiol (CBD) the drug was tested in an elevated plus-maze model of anxiety, in rats. Doses of 2.5, 5.0 and 10.0 mg/kg significantly increased the entry ratio (open/total number of entries), an anxiolytic-like effect. CBD at a dose of 20.0 mg/kg was no longer effective. None of the doses of CBD used changed total number of entries, a measure of total exploratory activity. Diazepam (2.0 mg/kg) also caused an anxiolytic-like effect in this model. These results indicate that CBD causes a selective anxiolytic effect in the elevated plusmaze, within a limited range of doses.
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Cunha JM, Carlini EA, Pereira AE, Ramos OL, Pimentel C, Gagliardi R, Sannito WL, Lander N, Mechoulam R (1980) Chronic administration of cannabidiol to healthy volunteers and epileptic patients. Pharmacology 21:175–185
Dewey WL (1986) Cannabidiol pharmacology. Pharmacol Rev 38:151–178
Grlie L (1976) A comparative study on some chemical and biological characteristics of various samples of cannabis resin. Bull Narc 14:37–46
Pellow S, File SE (1986) Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze. A novel test of anxiety in the rat. Pharmacol Biochem Behav 24:525–529
Pellow S, Chopin P, File SE, Briley M (1985) Validation of open: closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Methods 14:149–167
Silveira Filho NG, Tufik S (1981) Comparative effects between cannabidiol and diazepam on neophobia, food intake and conflict behavior. Res Commun Psychol Psychiatr Behav 6:25–66
Sofia RD, Kubena RK, Barry H (1971) Comparison of four vehicles for intraperitoneal administration of 1-tetrahydrocannabinol. J Pharm Pharmacol 23:889–891
Zuardi AW, Karniol IG (1983) Changes in the conditioned emotional response of rats induced by 9-THC, CBD and mixture of the two cannabinoids. Arq Biol Tecnol 26:391–397
Zuardi AW, Shirakawa I, Finkelfarb E, Karniol IG (1982) Action of cannabidiol on the anxiety and other effects produced by 9-THC in normal subjects. Psychopharmacology 76:245–250
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Guimarães, F.S., Chiaretti, T.M., Graeff, F.G. et al. Antianxiety effect of cannabidiol in the elevated plus-maze. Psychopharmacology 100, 558–559 (1990). https://doi.org/10.1007/BF02244012
- Elevated plus-maze