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Gastric blood flow following simultaneous administration of serotonin and histamine

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The American Journal of Digestive Diseases Aims and scope Submit manuscript

Summary

Left gastric-artery flow was measured with a Medicon FM-6 gated sine-wave electromagnetic flowmeter. Histamine, 4 µg./min., produces a small increase (9%) in flow. Serotonin in increasing doses of 10, 20, 40, and 60 µg./kg./min. given concomitantly with the same dose of histamine, progressively augment left gastric-artery flow in increments of 25, 43, 87, and 189%, respectively. The increases in left gastric-artery flow found with increasing doses of serotonin represent a single, direct, exponential relationship.

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References

  1. Peter, E. T., Nicoloff, D. M., Sosin, H., Walder, A. I., andWangensteen, O. H. Relationship between gastric blood flow and secretion.Fed. Proc. 21: (2)264, 1962.

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  2. Nicoloff, D. M., Sosin, H., Peter, E. T., Bernstein, E. F., andWangensteen, O. H. The effect of serotonin on gastric secretion.Am. J. Digest. Dis. 8:267, 1963.

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  3. Code, C. F., Blackburn, C. M., Livermore, G. R., Ratke, H. A method for the quantitative determination of gastric secretory inhibition.Gastroenterology 13:573, 1949.

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Authors and Affiliations

  1. From the Department of Surgery, University of Minnesota Medical School, Minneapolis, Minn.

    Henry Sosin M.D., Eugene F. Bernstein M.D., Edward T. Peter M.D. & Owen H. Wangensteen M.D.

Authors
  1. Henry Sosin M.D.
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  2. Eugene F. Bernstein M.D.
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  3. Edward T. Peter M.D.
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  4. Owen H. Wangensteen M.D.
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Additional information

Supported by U.S.P.H.S. Grant AM-02150 and by the Donald J. Cowling Fund for Surgical Research.

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Sosin, H., Bernstein, E.F., Peter, E.T. et al. Gastric blood flow following simultaneous administration of serotonin and histamine. Digest Dis Sci 9, 92–96 (1964). https://doi.org/10.1007/BF02243512

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  • DOI: https://doi.org/10.1007/BF02243512

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