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Reduced sulphoxidation capacity in D-Penicillamine induced myasthenia gravis

Clinical Rheumatology volume 13, pages 435–437 (1994)Cite this article

Summary

Myasthenia gravis may be observed due to treatment with penicillamine (D-PA). The sulphoxidation capacity was measured in nine Swedish patients with rheumatoid arthritis (RA) who had developed myasthenia gravis toward D-PA. The results show that in eight of nine patients tested, this parameter was markedly reduced. A patient with poor sulphoxidation capacity has a twelve-fold greater risk of developing this rare side effect. The significance of this is discussed.

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Affiliations

  1. Department of Internal Medicine, Divisions of Rheumatology, Karolinska Institute, S-182 88, Danderyd, Sweden

    P. Seideman

  2. Department of Pharmacology, St Mary's Hospital, Medical School, London, England

    R. Ayesh

Authors
  1. P. Seideman
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  2. R. Ayesh
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Seideman, P., Ayesh, R. Reduced sulphoxidation capacity in D-Penicillamine induced myasthenia gravis. Clin Rheumatol 13, 435–437 (1994). https://doi.org/10.1007/BF02242938

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  • DOI: https://doi.org/10.1007/BF02242938

Key words

  • Penicillamine
  • Adverse Reaction
  • Sulphoxidation Capacity
  • Myasthenia Gravis