Clinical Rheumatology

, Volume 13, Issue 3, pp 427–432 | Cite as

Clinical correlation of anticentromere antibodies

  • M. Zuber
  • R. Gotzen
  • I. Filler
Bookreviews Originals


A retrospective survey of all patients with a positive anticentromere antibody (ACA) determination was undertaken over a 3-years period of time in a university hospital. Forty-five patients were positive for anticentromere antibodies. The analysis of the clinical characteristics and diagnoses of the patients with anticentromere antibodies were correlated and showed a diverse array of symptoms. Only 4.4% had CREST syndrome, 6.7% had limited scleroderma, 17.8% had diffuse scleroderma, 20% had other connective tissue diseases, 20% had other miscellaneous rheumatic conditions, 11.1% had tumours and 20% other nonrheumatic diseases. The study shows that the presence of ACA, as detected during routine ANA-testing, does not strongly suggest a diagnosis of CREST at that time. The presence of a scleroderma-variant in almost 50% of the patients and the occurrence of Raynaud's phenomenon in 62% underscores, however, an association of ACA with (early) scleroderma-like disorders.

Key words

Anticentromere Antibodies Antinuclear Antibodies Autoantibodies CREST Syndrome Scleroderma 


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Copyright information

© Clinical Rheumatology 1994

Authors and Affiliations

  • M. Zuber
    • 1
  • R. Gotzen
    • 2
  • I. Filler
    • 2
  1. 1.German Research Center for RheumatologyBerlinGermany
  2. 2.Department of Internal MedicineSteglitz University Medical CenterBerlinGermany

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