Summary
A 45-year-old man with Dubin-Johnson syndrome had a delayed elevation in serum BSP. This phenomenon has been reported in previous patients with this syndrome. It did not occur in a patient with the closely related Rotor's syndrome, or in 4 patients with jaundice due to cirrhosis, cholestasis, chronic viral hepatitis, and cholangiolitic hepatitis. This finding may be useful in the diagnosis of the Dubin-Johnson syndrome, particularly if liver biopsy is not possible or is contraindicated. It may also aid in defining the indication for liver biopsy in family studies.
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References
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The authors wish to thank Dr. J. Carbone, Mr. R. Fanska, and Miss V. Hjelte who assisted with bromsulfalein fractionation, and Dr. W. Strauss who referred the patient for study.
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Dollincer, M.R., Brandborg, L.L. Late elevation in serum bromsulfalein in Dubin-Johnson syndrome. Digest Dis Sci 12, 413–417 (1967). https://doi.org/10.1007/BF02241946
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DOI: https://doi.org/10.1007/BF02241946