Conclusion
This study indicates that the instrument of cold can, under appropriate conditions, markedly alter the ability of the intact stomach to secrete acid. In general, the degree of reduction in acid production is directly related to the degree of hypothermia employed and is accompanied by a marked decrease in parietal- and chief-cell mass. The effectiveness of a single episode of hypothermia in the rat stomach is a consequence of the fact that a uniform freeze of precise duration is easily attained. Thus, the work presented here confirms and extends the observations of Buchanet al. 9, 10 and gives an indication of the biologic potential of gastric hypothermia.
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Supported by a U. S. Public Health Service grant, the John A. Hartford Foundation, and the Donald J. Cowling Fund for Surgical Research.
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Ritchie, W.P., Breen, J.J. & Wangensteen, O.H. Freezing of the intact rat stomach: An indication of the biologic potential of the technic. Digest Dis Sci 12, 379–388 (1967). https://doi.org/10.1007/BF02241940
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DOI: https://doi.org/10.1007/BF02241940