Nonparallel gastric and salivary gland inhibition produced by anticholinergic drugs in sham-fed dogs
- 15 Downloads
After esophagostomy and gastrostomy dogs were sham fed at timed intervals after a single intravenous injection of atropine, heteronium bromide, or saline. For each interval the doses necessary to reduce gastric juice volume and saliva weight by 50% were determined (50% doses). At 20- and 40-min. intervals gastric secretion was more sensitive than salivary secretion to anticholinergic inhibition, whereas at 100 and 160 min. the sensitivity was approximately equal. The change in the ratio of salivary 50% dose to gastric 50% dose demonstrates that gastric inhibition and salivary inhibition with either drug are not parallel.
KeywordsPublic Health Bromide Salivary Gland Atropine Intravenous Injection
Unable to display preview. Download preview PDF.
- 1.Pavlov, I. P. The Work of the Digestive Glands (Ed. 2). Griffin, London, 1910, p. 53.Google Scholar
- 2.Piper, D. W., Sietsma, A. S., andPryor, A. W. The effect of a new anticholinergic agent oxyphencyclimine hydrochloride on gastric secretion.Med J Aust 47:236, 1960.Google Scholar
- 3.Piper, D. W., andStiel, M. C. A comparison of a series of newer anticholinergic agents with atropine as regards their effect on saliva flow and gastric secretion.Gut 3:65, 1962.Google Scholar
- 4.Herxheimer, A. A comparison of some atropine-like drugs in man, with particular reference to their end organ specificity.Brit J Pharmacol 13:184, 1958.Google Scholar
- 5.Kirsner, J. B., Levin, E., andPalmer, W. L. Observations on the excessive nocturnal gastric secretion in patients with duodenal ulcer.Gastroenterology 11: 598, 1948.Google Scholar
- 6.Sun, D. C. H. Long-term anticholinergic therapy for prevention of recurrences in duodenal ulcer.AmerJ Dig Dis 9:706, 1964.Google Scholar
- 7.Kubin, R. H., Keeler, W. R., andKlotz, A. P. Influence of route of administration on therapeutic ratio of atropine in sham-fed dogs.Amer J Dig Dis 12: 363, 1967.Google Scholar