The American Journal of Digestive Diseases

, Volume 12, Issue 4, pp 371–378 | Cite as

Nonparallel gastric and salivary gland inhibition produced by anticholinergic drugs in sham-fed dogs

  • Robert H. Kubin
  • William R. Keeler
  • Arthur P. Klotz


After esophagostomy and gastrostomy dogs were sham fed at timed intervals after a single intravenous injection of atropine, heteronium bromide, or saline. For each interval the doses necessary to reduce gastric juice volume and saliva weight by 50% were determined (50% doses). At 20- and 40-min. intervals gastric secretion was more sensitive than salivary secretion to anticholinergic inhibition, whereas at 100 and 160 min. the sensitivity was approximately equal. The change in the ratio of salivary 50% dose to gastric 50% dose demonstrates that gastric inhibition and salivary inhibition with either drug are not parallel.


Public Health Bromide Salivary Gland Atropine Intravenous Injection 
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Copyright information

© Hoeber Medical Division • Harper & Row, Publishers, Incorporated 1967

Authors and Affiliations

  • Robert H. Kubin
    • 1
  • William R. Keeler
    • 1
  • Arthur P. Klotz
    • 1
  1. 1.From the Gastrointestinal Laboratory and Department of SurgeryUniversity of Kansas Medical CenterKansas City

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