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Bovine Babesiosis: Sterile immunity toBabesia bigemina andBabesia argentina infections

Babesioses bovines: Immunite Sterile aux Infections aBabesia bigemina etB. argentina

Babesiosis Bovina: Immunidad esteril para infecciones deBabesia bigemina n Babesia argentina

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Summary

KilledBabesia bigemina andBabesia argentina vaccine was prepared from the infected erythrocytes and from the infected plasma (AG-S) collected from acutely infected calves withbigemina andargentina. The vaccine was tested in Colombian cattle under field conditions in the Cauca Valley. A total of 40 calves two and one half months of age received killed-Babesia vaccine, and 5 calves were not vaccinated; they served as controls. Vaccinated and non-vaccinated control calves were exposed to field-borne challenge withBoophilus microplus infected ticks. On the basis of the data obtained in these experiments, it was found that a high degree of sterile immunity toBabesia bigemina andBabesia argentina can be produced in calves injected with killed-Babesia vaccine. It appears that sterile immunity plays an important role in the mechanism of acquired immunity to babesiosis other than the well-known co-infectious immunity known as premunition.

Résumé

Des vaccins tués deBabesia bigemina etB. argentina ont été préparés à partir d'érythrocytes infectés et de plasma infecté récoltés chez des veaux présentant une infection élevée. Le vaccin a été testé, dans les conditions naturelles, chez du bétail colombien, dans la vallée Cauca. 40 veaux agés de 2 mois et demi ont reçu le vaccin tué, et 5 veaux, servant de témoins, n'ont pas été vaccinés. Les veaux vaccinés et les veaux témoins ont été exposés aux attaques de tiques (Boophilus microplus) infectées, nées sur le terrain. En se basant sur les résultats obtenus au cours de ces expériences, on constate qu'un degré élevé d'immunité stérile aux infectionsa B. bigemina etB. argentina peut être obtenu chez les veaux ayant reçu le vaccin tué. Il apparaît que l'immunité stérile joue un rôle important dans le mécanisme de l'immunité acquise, différent de l'immunité par infections légères res entretenues, telles que la prémunition.

Sumario

Se prepararon vacunas con cepas muertas deBabesia bigemina yBabesia argetina obtenidas de eritiocitos infectados (AG-E) y de plasma infectado (AG-S) obtenidos de terneros agudomente infectados conBabesia spp. La vacina fue provada en ganado Colombiano bajo condiciones de campo en el departemento del Valle del Cauca. Se tomaron en total 40 terneros de 2–1/2 meses de edad los cuales recibieron vacinas deBabesia muertas, cinco terneros no vacunados sirvieron como controles. El terneros vacunados y no vacunados fueron expuestos a la accion deBoophilus microplus infectados. Teniendo en cuenta los resultados obtenidos en esos experimentos, se encontro que un alto grado de inmunidad esteril paraBabesia bigemina y paraBabesia argentina puede ser producido en terneros njectados ocn vacunas deBabesia muertas. Parece que la inmunidad esteril tiene uno mportancia similar a la inmunidad adquirido por infeccion llamada premunision.

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Authors and Affiliations

  1. Institute of Tropical Veterinary Medicine, College of Veterinary Medicine, Texas A&M University, 77843, College Station, Texas

    R. A. Todorovic & L. G. Adams

  2. Instituto Colombiano Agropecuario, Palmira, Colombia

    E. F. Gonzalez

Authors
  1. R. A. Todorovic
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  2. E. F. Gonzalez
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  3. L. G. Adams
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Todorovic, R.A., Gonzalez, E.F. & Adams, L.G. Bovine Babesiosis: Sterile immunity toBabesia bigemina andBabesia argentina infections. Trop Anim Health Prod 5, 234–245 (1973). https://doi.org/10.1007/BF02240424

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