Summary
Manometric investigation of intestinal function in hypothyroidism has shown evidence of a severe functional deficiency of the small intestine and colon under both basal and stimulated conditions. Stimulating the small intestine by a glucose perfusion and the colon with Urecholine has shown a total absence of motor response in some of the patients affected by a particularly severe constipation. Urecholine stimulation of the colon may provide a prognostic test by showing which patients will respond to hormonal therapy by restoration of normal intestinal function.
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Duret, R.L., Bastenie, P.A. Intestinal disorders in hypothyroidism. Digest Dis Sci 16, 723–727 (1971). https://doi.org/10.1007/BF02239597
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DOI: https://doi.org/10.1007/BF02239597